菊苣全草化学成分的基础研究  

Study on Chemical Constituents of the Herb of Cichorium intybus L.

作　　者：娄猛猛[1] 李国玉[1] 赵文斌[1] 王金辉[1,2] 

机构地区：[1]石河子大学药学院/教育部省部共建新疆特种植物药资源重点实验室,石河子832002 [2]沈阳药科大学中药学院,沈阳110016

出　　处：《石河子大学学报（自然科学版）》2011年第2期210-214,共5页Journal of Shihezi University(Natural Science)

基　　金：国家重大新药创制项目(2010ZX09401-304)

摘　　要：对菊苣全草的化学成分进行分离鉴定。采用溶剂提取、萃取、反复硅胶柱色谱、Sephadex LH-20、制备薄层色谱法等方法进行分离纯化,根据化合物的理化性质和光谱数据鉴定其结构。结果显示分离得到6个化合物,鉴定为橙黄胡椒酰胺(2S,2′S-Aurantiamide acetate,Ⅰ)、对羟基苯乙酸甲酯(methyl p-hydroxyl benzeneacetate,Ⅱ)、木犀草素-7-O--βD-葡萄糖苷(luteolin-7-O--βD-glucoside,Ⅲ)、木犀草素(luteolin,Ⅳ)、咖啡酸(caffeic acid,Ⅴ)、(-谷甾醇((-sitosterol,Ⅵ)。由此可知,化合物Ⅰ为首次从本属植物中分离得到,化合物Ⅱ为首次从菊苣中分离得到。To investigate the chemical constitutes of Cichorium intybus L.,the compounds were isolated by means of solvent extraction,Abstraction,chromatography on silica gel,Sephdex LH-20,PLC.The structures were identified by spectral analysis and chemical evidence.Six compounds were isolated from the Cichorium intybus L.and were identified as Aurantiamide acetate（Ⅰ）,methyl p-hydroxyl benzeneacetate（Ⅱ）,luteolin-7-O-β-D-glucoside（Ⅲ）,luteolin（Ⅳ）,caffeic acid（Ⅴ）,（-sitosterol（Ⅵ）.Aurantiamide Acetate was isolated from the Cichorium genus for the first time;Methyl p-hydroxyl benzeneacetate was isolated from Cichorium intybus L.for the first time.

关 键 词：菊苣 化学成分 结构鉴定 

分 类 号：R914[医药卫生—药物化学] R284[医药卫生—药学]