精神分裂症患者血清BDNF的表达及相关研究  

Expression and significance of plasma BDNF in patients with schizophrenia

作　　者：曾妍[1] 况利[1] 甘窈[1] 陈建梅[1] 艾明[1] 王我[1] 苟芯源[1] 王俊[1] 徐小明[1] 

机构地区：[1]重庆医科大学附属第一医院心理卫生中心,重庆400016

出　　处：《重庆医科大学学报》2011年第4期476-478,共3页Journal of Chongqing Medical University

基　　金：重庆市卫生局科研资助项目(编号:07-2-049)

摘　　要：目的:探讨精神分裂症患者血清脑源性神经营养因子(Brainderived neurotrophic factor,BDNF)的水平和特点。方法:收集精神分裂症患者44名和正常对照者45名,使用阳性和阴性症状量表(The positive and negative syndrome scale,PANSS)对患者疾病的严重程度进行评分,使用酶联免疫吸附法检测血清BDNF水平,用SPSS18.0软件对数据进行统计分析。结果:患者血清BDNF水平明显低于正常对照人群(P<0.01);患者血清BDNF水平与其病程和疾病严重程度无明显相关。结论:BDNF可能成为精神分裂症的生物学标志物之一。Objective： To investigate the characteristics of plasma brain-derived neurotrophic factor （ BDNF ） levels in patients with schizophrenia and the possibility of BDNF as the biological marker of schizophrenia. Methods ： 44 patients with schizophrenia and 45 matched normal controls were enrolled.Assessment was performed with Positive and Negative Syndrome Scale （ PANSS ） , and serum BDNF levels were detected by ELISA.All data were analyzed by SPSS18.0. Results：①Serum BDNF levels in patients with schizophrenia were significantly decreased compared with those in normal controls （ P 〈 0.01 ） ;②No significant correlation was found between serum BDNF levels in patients and their severities of schizophrenia. Conclusion： BNDF may be a candidate biological marker of schizophrenia.

关 键 词：精神分裂症 血清 脑源性神经营养因子 

分 类 号：R749.3[医药卫生—神经病学与精神病学]