表没食子儿茶素没食子酸酯对胃癌肿瘤血管生成的影响  

Antiangiogenic Effect of(-)-Epigallocatechin-3-Gallate on Gastric Cancer

作　　者：吴宏菊[1] 胡跃云[1] 李文会[1] 陈宏[1] 肖玉平[1] 辛彦[1] 

机构地区：[1]中国医科大学附属第一医院肿瘤研究所第四研究室,普通外科研究所肿瘤病理研究室,沈阳110001

出　　处：《中国医科大学学报》2011年第6期494-496,共3页Journal of China Medical University

基　　金：国家自然科学基金资助项目(30973503、81071650和81050007);辽宁省高校攀登学者支持计划(2009-2011);高等学校博士学科点专项科研基金(20092104110008);沈阳市科学技术计划项目(F10-149-9-45)

摘　　要：目的探讨表没食子儿茶素没食子酸酯(EGCG)对胃癌肿瘤血管生成的影响及其机制。方法建立人胃腺癌BGC-823细胞裸鼠移植瘤模型,观察肿瘤生长及毒副作用。免疫组化染色测定CD31和血管内皮生长因子(VEGF)表达。结果与对照组比较,EGCG明显抑制了肿瘤的生长,EGCG组的平均瘤重明显低于对照组(P<0.05),抑瘤率达38.29%,毒副反应没有增加,同时肿瘤组织内的微血管密度(MVD)及VEGF表达下降(P<0.05)。结论 EGCG能够有效抑制裸鼠胃癌移植瘤的生长及微血管的形成,没有明显的毒副作用,其机制可能与减少VEGF的表达相关。Objective To investigate the antiangiogenic effect of （-）-epigallocatechin-3-gallate （EGCG） on gastric： cancer and to explore its mechanism. Methods BGC-823 human gastric cancer xenograft mode] was constructed. Tumor growth and side effects were closely monitored. Expression of VEGF and CD31 were observed by immunohistochemistry. Results Compared with the control group, EGCG significantly inhibited BCC-823 tumor growth in the absence of toxicity. ; the average tumor weight was markedly lower in the EGCG group （ P 〈 0.05）,with 38.29% suppression of the primary tumor growth. This was eompanied by the decrease of micmvessel density （MVD） and VECF gene expression in the turnout tissues. Conclusion EGCG can effectively inhibit the growth of gastric turnout and the formation of micmvessels with no apparent side effects. This effect may be associated with reduced expression of VEGF.

关 键 词：血管生成 表没食子儿茶素没食子酸酯 胃肿瘤 

分 类 号：R735.2[医药卫生—肿瘤]