小针剂配伍输液中细菌内毒素的定量测定  

Quantitative analysis method of bacterial endotoxin for the small-volume injection and infusion combination

作　　者：詹云丽[1] 李楚云[2] 刘杜妙[1] 翁嘉[1] 

机构地区：[1]广东省惠州市药品检验所,惠州516003 [2]惠州市中心人民医院,惠州516001

出　　处：《药物分析杂志》2011年第6期1181-1184,共4页Chinese Journal of Pharmaceutical Analysis

基　　金：广东省惠州市科技计划项目(2009Y014)

摘　　要：目的:建立小针剂配伍输液中细菌内毒素的含量分析方法,减少临床热原反应的发生。方法:采用中国药典2005年版二部动态浊度法检测混合药液中细菌内毒素的含量,并对18组临床输液残液进行检测。结果:混合药液经稀释后能排除干扰。结论:动态浊度法测定此类混合药液中细菌内毒素含量是可行的。Objective：To establish a method for analyzing the contents of bacterial endotoxin in the compatibility of small-volume injection and infusion.The occurrence of clinical pyrogen reactions can be reduced.Methods：According to ChP.2005.VolⅡ,dynamic turbidimetric assay is adopted to test the contents of bacterial endotoxin in the combined medication as well as 18 groups of residual liquid of fluid infusion.Results：The mixed infusion had no interference on the test by diluting.Conclusion：Determination of bacterial endotoxin content of this mixture is available by dynamic turbidimetric assay.

关 键 词：细菌内毒素 输液 配伍 动态浊度法 

分 类 号：R917[医药卫生—药物分析学]