WT1与NF-кB在卵巢浆液性肿瘤中的表达及意义  

Expression and significance of WT1 and NF-кB in serous ovarian tumor

作　　者：孔艳青[1] 孙振柱[2] 

机构地区：[1]新疆医科大学基础医学院病理教研室 [2]新疆维吾尔自治区人民医院病理科,新疆乌鲁木齐830000

出　　处：《新疆医科大学学报》2011年第4期358-361,共4页Journal of Xinjiang Medical University

摘　　要：目的探讨WT1和NF-кB/p65在卵巢浆液性肿瘤中的表达与临床病理学特征的关系。方法采用免疫组化Envision二步法检测WT1和NF-кB/p65在卵巢良性浆液性肿瘤(40例)、交界性浆液性肿瘤(40例)和浆液性癌(40例)中的表达情况,分析其表达水平与卵巢浆液性肿瘤临床病理特征的相关性。结果 WT1在卵巢良性浆液性肿瘤、交界性浆液性肿瘤和浆液性癌组织中阳性率分别为22.5%、72.5%和90.0%。卵巢浆液性癌及交界性浆液性肿瘤中WT1的表达明显高于良性浆液性肿瘤(P<0.05)。NF-кB/p65在卵巢浆液性癌和交界性肿瘤中的表达率分别为77.5%和62.5%,明显高于良性肿瘤(P<0.05),卵巢浆液性癌中NF-кB/p65的表达与肿瘤的大小关系密切(P<0.05),WT1的表达和NF-кB的表达呈正相关(r=0.419)。结论卵巢浆液性癌中存在WT1和NF-кB的高表达,二者可能与卵巢浆液性肿瘤的发生发展有关。Objective To investigate the expression of WT1 and NF-кB in serous ovarian tumor,and to discuss the clinical significance and their correlation.Methods The expressions of WT1 and NF-кB proteins were detected by immunohistochemisty in serous ovarian cancer（40 cases）,borderline ovarian tumor（40 cases） and benign ovarian tumor（40 cases） respectively.Analysed the correlation express level ovary serous tumor clinical pathology characteristic.Results The positivity rates of WT1 of benign tumors,borderline tumors and serous ovarian cancers were 22.5%,72.5% and 90%,22.5% respectively.The WT1 expression in serous ovarian cancers and borderline tumors was significantly higher than that in benign tumors（P0.05）.The positivity rates of NF-кB/p65 in serous ovarian cancers and borderline tumors were 77.5% and 62.5% respectively,significantly higher than that in benign tumors（P0.05）.The over expression of NF-кB/p65 was related to the volume of serous ovarian cancer（P0.05）.The expression of WT1 was correlated with NF-кB（P0.05）.Conclusion WT1 and NF-кB are over expressed in ovarian serous cancer.A high expression of WT1 and NF-кB is considered associating with the evolution and progression of serous ovarioan tumor.

关 键 词：卵巢浆液性肿瘤 WT1 NF-кB/p65 

分 类 号：R737.31[医药卫生—肿瘤]