GC/MS研究海洛因代谢物在吸毒者体内的分布  

Determination of heroin metabolites in biological fluids,tissues and hair of heroin addicts using GC/MS-SIM

作　　者：向平[1] 沈敏[1] 吴何坚[1] 黄仲杰[1] 

机构地区：[1]司法部司法鉴定科学技术研究所,上海200063

出　　处：《法医学杂志》1999年第4期208-210,共3页Journal of Forensic Medicine

摘　　要：应用GC／MS－SIM测定了海洛因代谢物吗啡在两例海洛因延缓死亡者的体内分布，并分析了收集到的7例案子的毛发（头发、腋毛和阴毛）中6-单乙酰吗啡和吗啡含量。生物检材和毛发经酸水解、提取、醋酸酐或双（三甲基硅基）三氟乙酰胺（BSTFA）衍生化，然后进行GC／MS-SIM分析。结果表明尿、胆汁和肝脏是判定死者是否曾使用海洛因的最佳检材；毛发分析与生物检材相比有其独特的优点，可提供数月甚至数年的用药情况。为公安司法机关打击吸毒、惩治犯罪提供更可靠、有效的证据。Using GC/MS - SIM, we examined morPhine distribution in human bodies of 2 delayed death cases and analyzed content of morphine and 6 - acetylmorphine (MAM) in hair specimens of 7 cases. Afer hydrolysis and extraction, MoR and 6 - MAM were derived with acetic anhydride or BSTFA and then the derivatives were qualitatively and quantitatively analyzed by GC/MS SIM. The results indicated that urine, bile and liver were the best samples to reveal the heroin - related deaths. Hair analysis has its unique advantage for its long time of abusing monitor, compared to biological fluids.

关 键 词：GC MS SIM 体液 组织 毛发 吗啡 单乙酰吗啡 

分 类 号：D919.1[医药卫生—法医学] R595.502[政治法律—法学]