28小时完全睡眠剥夺对机体神经行为功能的影响  

Effects of 28-h total sleep deprivation on Neurobehavioral functions

作　　者：张凯[1] 秦茂森[1] 郭娜[1] 廖凯举[1] 张雅楠[1] 

机构地区：[1]济宁医学院医学检验系,山东济宁272067

出　　处：《济宁医学院学报》2011年第3期191-193,196,共4页Journal of Jining Medical University

摘　　要：目的探讨28 h完全睡眠剥夺对机体神经行为功能的影响。方法采用自身前后对照设计,对18名健康大学生进行28 h的睡眠剥夺,受试者每隔4 h进行一次情绪状态、反应时和瞬时记忆的测试。结果所有5项消极情绪分值都增加,其中紧张焦虑(F=2.83,P=0.042)、抑郁沮丧(F=3.36,P=0.035)、疲劳惰性(F=4.71,P<0.01)、困惑迷茫(F=3.58,P=0.029)等情绪分值的差异有统计学意义;有力好动分值下降,其差异具有统计学意义(F=3.03,P=0.049)。简单反应时、辨别反应时和选择反应时呈线性延长,其中选择反应时延长具有统计学意义(F=2.52,P=0.026)。瞬时记忆的错误数明显增加(F=8.88,P<0.01)。结论长时间睡眠剥夺可使机体神经行为功能明显受损。Objective To investigate the effect of 28-h sleep deprivation on neurobehavioral functions.Methods A series of tests such as POMS,reaction time,instantaneous memory were measured in 18 healthy undergraduate students every 4 h during 28-h total sleep deprivation（TSD）.Results The negative mood states such as tension-anxiety（F=2.83,P=0.042）,depression-dejection（F=3.36,P=0.035）,fatigue-inertia（F=4.71,P0.01） and confusion-Bewilderment（F=3.58,P=0.029）showed a linear increase with accumulating hours of TSD,while the positive mood state of vigor-activity（F=3.03,P=0.049）showed a linear decrease.The reaction time especially the selective reaction time prolonged significantly（F=2.52,P=0.026）.The wrong numbers（F=8.88,P0.01） increased significantly after 28-h TSD.Conclusion Neurobehavioral functions were impaired by 28-h TSD.

关 键 词：睡眠剥夺 POMS 反应时 瞬时记忆 

分 类 号：R740[医药卫生—神经病学与精神病学]