MicroRNA的基础与临床研究进展  

Research and development of basic and clinical for microRNA

作　　者：郭晓瑞[1] 吴志远[1] 黄海华[1] 罗少军[1] 梁杰[1] 

机构地区：[1]广东医学院附属医院整形外科研究所,湛江524001

出　　处：《中国实用医药》2011年第15期256-258,共3页China Practical Medicine

基　　金：广东省科技计划项目资助(项目编号:2010B031600286)

摘　　要：MicroRNA是新近发现的一类调控性小分子RNA,通过降解靶基因mRNA或转录后抑制靶基因表达而发挥作用。近期的研究发现人血清中稳定存在一定水平的miRNA,并且血清miRNA表达谱的变化与多种肿瘤的发生、发展具有明确的相关性,说明血清miRNA可以作为肿瘤临床诊断和预后评估的分子标志物。MicroRNAsare small noncoding RNAsthat functionto regulate gene expression by post-transcription regulation or degradation mRNA of target gene.Recently,it has been shown that serum contains large amounts of stable miRNAs and that the serum miRNA expression profile can be used as a novel serum-based biomarker potentially offering more sensitive and specific tests than those currently available for early diagnosis of cancer and other diseases.

关 键 词：MICRORNA 基因调控 疾病 分子标志物 

分 类 号：R730.2[医药卫生—肿瘤]