Current understanding of KATP channels in neonatal diseases： focus on insulin secretion disorders  

作　　者：Yi QUAN Andrew BARSZCZYK Zhong-ping FENG Hong-shuo SUN 

机构地区：[1]Departments of Physiology Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada, M5S 1A8 [2]Departments of Surgery Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada, M5S 1A8 [3]Departments of Pharmacology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada, M5S 1A8 [4]Departments of Institute of Medical Science, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada, M5S 1A8

出　　处：《Acta Pharmacologica Sinica》2011年第6期765-780,共16页中国药理学报（英文版）

摘　　要：ATP-sensitive potassium （KATP） channels are ceil metabolic sensors that couple cell metabolic status to electric activity, thus regulat- ing many cellular functions. In pancreatic beta cells, KATp channels modulate insulin secretion in response to fluctuations in plasma glucose level, and play an important role in glucose homeostasis. Recent studies show that gain-of-function and loss-of-function mutations in KATP channel subunits cause neonatal diabetes mellitus and congenital hyperinsulinism respectively. These findings lead to significant changes in the diagnosis and treatment for neonatal insulin secretion disorders. This review describes the physiological and pathophysiological functions of KATP channels in glucose homeostasis, their specific roles in neonatal diabetes mellitus and congenital hyperinsulinism, as well as future perspectives of KATp channels in neonatal diseases.ATP-sensitive potassium （KATP） channels are ceil metabolic sensors that couple cell metabolic status to electric activity, thus regulat- ing many cellular functions. In pancreatic beta cells, KATp channels modulate insulin secretion in response to fluctuations in plasma glucose level, and play an important role in glucose homeostasis. Recent studies show that gain-of-function and loss-of-function mutations in KATP channel subunits cause neonatal diabetes mellitus and congenital hyperinsulinism respectively. These findings lead to significant changes in the diagnosis and treatment for neonatal insulin secretion disorders. This review describes the physiological and pathophysiological functions of KATP channels in glucose homeostasis, their specific roles in neonatal diabetes mellitus and congenital hyperinsulinism, as well as future perspectives of KATp channels in neonatal diseases.

关 键 词：ATP-sensitive potassium （KATp） channels CHANNELOPATHY neonatal diabetes congenital hyperinsulinism glucose homeostasis DIAZOXIDE SULFONYLUREAS 

分 类 号：Q424[生物学—神经生物学] S814.1[生物学—生理学]