SULFONYLUREAS

作品数：22被引量：50H指数：4
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相关领域：医药卫生农业科学更多>>
相关机构：南开大学更多>>
相关期刊：《Chinese Journal of Integrative Medicine》《Journal of Diabetes Mellitus》《Acta Pharmacologica Sinica》《Science China Chemistry》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划天津市自然科学基金泰国研究基金更多>>
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Generation of sulfonylureas under photoredox catalysis and their biological evaluations
《Chinese Chemical Letters》2022年第11期4860-4864,共5页Xuefeng Wang Jun Zhang Qi Chen Wei Zhou Jie Wu 
Financial support from National Natural Science Foundation of China(No.21871053);the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(No.2019R01005);the Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(No.2020ZD04)。
Traditional synthesis of sulfonylureas largely depends on nucleophilic addition of arylsulfonamides to presynthesized isocyanates.Now we report a new access to alkylsulfonylureas with good yields and broad substrate s...
关键词：SULFONYLUREA Chlorosulfonyl isocyanate PHOTOCATALYSIS 
Anti-aging effects of chlorpropamide depend on mitochondrial complex-Ⅱ and the production of mitochondrial reactive oxygen species被引量：4
《Acta Pharmaceutica Sinica B》2022年第2期665-677,共13页Zhifan Mao Wenwen Liu Yunyuan Huang Tianyue Sun Keting Bao Jiali Feng Alexey Moskalev Zelan Hu Jian Li 
Financial support for this research provided by the National Natural Science Foundation of China(22037002 and 81772689);the Program for Professor of Special Appointment(Eastern Scholar TP2018025,China)at Shanghai Institutions of Higher Learning;the Innovative Research Team of High-level Local Universities in Shanghai;the Chinese Special Fund for State Key Laboratory of Bioreactor Engineering(2060204,China);Strains of Caenorhabditis elegans were provided by the CGC,which is funded by NIH Office of Research Infrastructure Programs(P40 OD010440)。
Sulfonylureas are widely used oral anti-diabetic drugs.However,its long-term usage effects on patients’lifespan remain controversial,with no reports of influence on animal longevity.Hence,the anti-aging effects of ch...
关键词：SULFONYLUREAS CHLORPROPAMIDE ANTI-AGING Mitochondrial complexⅡ Mitochondrial reactive oxygen species ATP sensitive potassium channels SENESCENCE Succinate dehydrogenase 
Clinical characterization and follow-up analysis of twenty-one cases with neonatal diabetes mellitus
《Journal of Hainan Medical University》2020年第11期51-55,共5页Xue Zhao Wei Gu 
Key projects for the development of medical science and technology in Nanjing (201823014)
Objective: We summarize the clinical and follow-up data of twenty-one children with neonatal diabetes mellitus (NDM) to strengthen the understanding of NDM and provide reference for clinical diagnosis and follow-up. M...
关键词：Neonatal diabetes mellitus(NDM) SULFONYLUREAS Clinical characterization Growth and development 
HNF1A mutation in a Thai patient with maturity-onset diabetes of the young: A case report被引量：1
《World Journal of Diabetes》2019年第7期414-420,共7页Nattachet Plengvidhya Watip Tangjittipokin Nipaporn Teerawattanapong Tassanee Narkdontri Pa-thai Yenchitsomanus 
Supported by Mahidol University Research Grant,Nos.R015810001and 016120003(to Nattachet Plengvidhya);Siriraj Research Grant for Research and Development,Faculty of Medicine Siriraj Hospital,Mahidol University,No.R015934015(to Tassanee Narkdontri and Watip Tangjittipokin);Thailand Research Fund grants,Nos.TRG5780113(to Watip Tangjittipokin),BRG5280008(to Nattachet Plengvidhya),and IRG5980006(to Pa-thai Yenchitsomanus)
BACKGROUND Maturity-onset diabetes of the young(MODY)is the most common form of monogenic diabetes.The disease is transmitted in autosomal dominant mode and diabetes is usually diagnosed before age 25 year.MODY 3 is c...
关键词：ORAL SULFONYLUREAS Maturity-onset diabetes of the YOUNG HNF1A Case report 
Polymorphisms of the KCNQ1 gene are associated with the therapeutic responses of sulfonylureas in Chinese patients with type 2 diabetes被引量：4
《Acta Pharmacologica Sinica》2017年第1期80-89,共10页Qing LI Ting-ting TANG Feng JIANG Rong ZHANG Miao CHEN Jun YIN Yu-qian BAO Xiang CHENG Cheng HU Wei-ping JIA 
KCNQ1 channel is a member of the voltage-gated potassium channel KQT-like subfamily. The KCNQ1 gene has recently been identified as a susceptibility locus for type 2 diabetes mellitus （T2DM）. In the present study, w...
关键词：potassium channel KCNQ1 type 2 diabetes SULFONYLUREAS gliclazide MR PHARMACOGENETICS 
Design, Synthesis and Herbicidal Activity of Novel Sulfonylureas Containing Triazole and Oxadiazole Moieties被引量：1
《Chemical Research in Chinese Universities》2016年第4期607-614,共8页ZHANG Dongkai HUA Xuewen LIU Ming WU Changchun WEI Wei LIU Yang CHEN Minggui ZHOU Sha LI Yonghong LI Zhengming 
Supported by the National Natural Science Foundation of China（No.21272129） and the Project of the Collaborative Innova- tion Center of Chemical Science and Engineering of Tianjin, China.
Three novel series of 5-substituted sulfonylurea derivatives were designed and synthesized via introducing a triazole or oxadiazole ring at the 5th position of the benzene ring in classical sulfonylurea herbicides. Al...
关键词：SULFONYLUREA Herbicidal activity TRIAZINE OXADIAZOLE 
Design, Synthesis and Herbicidal Activity of Novel Sulfonylureas Containing Tetrahydrophthalimide Substructure被引量：3
《Chemical Research in Chinese Universities》2016年第3期396-401,共6页HUA Xuewen ZHOU Sha CHEN Minggui ZHANG Dongkai LIU Ming LIU Jingbo WU Changchun LIU Yang LI Yonghong LI Zhengming 
Supported by the National Natural Science Foundation of China（No.21272129） and the Syngenta Doctorate Scholarship Program of China.
To develop novel sulfonylurea herbicides, a series of chlorsulfuron derivatives was designed and synthesized through introducing tetrahydrophthalimide substructure taken from protoporphyrinogen IX oxidase（PPO） inhib...
关键词：Sulfonylurea herbicide Tetrahydrophthalimde Herbicidal activity 
Design, Syntheses and Biological Activities of Novel Sulfonylureas Containing an Oxime Ether Moiety被引量：1
《Chemical Research in Chinese Universities》2016年第2期195-201,共7页WEI Wei CHENG Dandan CHEN Wei LIU Jingbo WAN Yingying LI Yuxin LI Yonghong YU Shujing LI Zhengming 
Supported by the National Natural Science Foundation of China（No.21272129）, the National Key Technology Research and Development Program of China（No.2011BAE06B05）, the ＂111＂ Project of the Ministry of Education of China（No.B06005） and the Project of the Synergetic Innovation Center of Chemical Science and Engineering of Tianjin, China.
Since sulfonylurea is one of the most potent acetohydroxyacid synthase（AHAS） inhibitors, a series of novel sulfonylureas containing an oxime ether moiety was designed and synthesized and their chemical structures we...
关键词：Acetohydroxyacid synthase SULFONYLUREA Oxime ether 
Sulfonylurea Glimepiride: A Proven Cost Effective, Safe and Reliable War Horse in Combating Hyperglycemia in Type 2 Diabetes
《Journal of Diabetes Mellitus》2015年第4期211-226,共16页Udaya M. Kabadi 
Recently, a debate has been raised regarding the place and the role of sulfonylureas (SU) amongst the armamentarium of drugs available for treatment of hyperglycemia in subjects with type 2 diabetes mellitus. With the...
关键词：Type 2 Diabetes SULFONYLUREAS (SU) 
Antidiabetic treatment, stroke severity and outcome被引量：3
《World Journal of Diabetes》2014年第2期84-88,共5页Dimitra Magkou Konstantinos Tziomalos 
Ischemic stroke is a leading cause of mortality and long-term disability worldwide. Given the detrimental effects of acute stroke, several neuroprotective agents have been evaluated in these patients. However, the ben...
关键词：Type 2 diabetes MELLITUS Stroke Dipeptidyl peptidase-4 inhibitors SULFONYLUREAS NEUROPROTECTION 
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