甘氨酸衍生物氨肽酶抑制剂的合成  

Synthesis of Glycine Derivatives as Aminopeptidase Inhibitors

作　　者：黄惠明[1,2] 梁辉[2] 李敏[2] 陈根林[2] 刘成梅[1] 

机构地区：[1]南昌大学食品科学与技术国家重点实验室,南昌330029 [2]南昌大学研究生院医学部,南昌330006

出　　处：《南昌大学学报（医学版）》2011年第3期8-12,共5页Journal of Nanchang University：Medical Sciences

摘　　要：目的探讨甘氨酸衍生物类氨肽酶N(APN)抑制剂类抗肿瘤药物的合成。方法通过对已知的类肽类APN抑制剂结构特征的总结,设计并合成3个系列酰胺衍生物。结果通过IR、MS和1H-NMR确定其化学结构,所合成的化合物1a-f、2a-f和3a-f均未见报道,为新化合物。结论化合物3b可以作为APN的先导化合物。Objective To explore the synthesis of glycine derivatives as aminopeptidase N（APN） inhibitors.Methods Based on the known structure of peptide-like derivatives as APN inhibitors,three series of acetamide derivatives were designed and synthesized.Results The chemical structure of acetamide derivatives was determined using IR,MS and 1H-NMR methods.The synthesized compounds 1a-f,2a-f and 3a-f were new compounds and had not be reported anywhere.Conclusion Compound 3b can be used as lead compound of APN.

关 键 词：氨肽酶N抑制剂 甘氨酸衍生物 化学合成 

分 类 号：R914[医药卫生—药物化学]