生长抑素类似物奥曲肽对人胃癌p53和Ras蛋白表达的影响  

Inhibitory effect of somatostatin analogue octreotide on the expression of p53 and Ras in human gastric cancer

作　　者：田蕾[1] 李舒[1] 

机构地区：[1]辽宁医学院附属第一医院消化内科,辽宁锦州121001

出　　处：《南方医科大学学报》2011年第7期1245-1248,共4页Journal of Southern Medical University

基　　金：辽宁省教育厅项目(L2010308)

摘　　要：目的探讨生长抑素类似物奥曲肽对人胃癌生长的抑制作用。方法 50例胃癌患者随机分为对照组25例,术前不用药物;奥曲肽组25例,术前奥曲肽100μg皮下注射,1次/d,共7d。术中切除标本送组织学研究。免疫组化法检测胃癌组织p53和Ras蛋白表达情况。结果与对照组比较,奥曲肽组胃癌组织坏死差异有统计学意义(P<0.05),纤维组织增生明显(P<0.05),p53和Ras蛋白表达有统计学意义(P<0.05)。结论奥曲肽通过抑制人体内胃癌p53和Ras蛋白的表达,从而发挥抑制胃癌细胞生长的作用。Objective To investigate the inhibitory effect of somatostatin（SST） analogue octreotide on human gastric cancer.Methods Fifty gastric cancer patients were randomly assigned into 2 equal groups.The patients in the control group received no medication before surgical resection of gastric cancer,and those in octreotide group were given daily subcutaneous injection of 100 μg octreotide for 7 days before the surgery.The resected specimens were examined histologically and the expressions of p53 and Ras protein were detected by immunohistochemistry.Results Compared with the control group,gastric cancer tissue in octreotide group showed significantly increased necrosis（P〈 0.05） and enhanced proliferation of fibrous tissues（P〈0.05） with lowered expressions of p53 and Ras protein（P〈0.05）.Conclusion Octreotide can inhibit the expressions of p53 and Ras and suppress the growth of the human gastric cancer.

关 键 词：胃癌 奥曲肽 P53 RAS 

分 类 号：R735.2[医药卫生—肿瘤]