Effects of GBE50 on hippocampal CA1 synaptic plasticity,learning and memory in an experimental rat model of aging  

作　　者：Lili Wu Xianwen Dong Gaiying He Zhixiong Zhang Ying Xu Xingyu Wang Yun Li 

机构地区：[1]Department of Physiology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

出　　处：《Neural Regeneration Research》2011年第12期892-897,共6页中国神经再生研究（英文版）

基　　金：the Scientific Research Program of the Shanghai Science and Technology Commission,No.09ZR1432100;the Key Subject Construction Program of Shanghai Education Commission,No.J50301;the Scientific Research Innovation Program of Shanghai Education Commission,No.08YZ59

摘　　要：The content of total flavonoids in an extract of Ginkgo biloba, called GBE50, is 44% by weight. This is significantly greater than that in a standard extract of Ginkgo biloba, designated EGB761. To date, the mechanisms by which GBE50 and EGB761 function remain poorly understood. In the present study, an experimental rat model of aging was induced by intraperitoneal injection of D-galactose, followed by intragastric perfusion of GBE50 （30, 60 mg/kg）, or EGB761 （60 mg/kg）. The water maze scores and hippocampal CA1 synaptic plasticity were evaluated. In the place navigation test, the GBE50 group rats did better than EGB761, while similar scores were obtained in the spatial probe test, and in the platform-switched test. In addition, long-term potentiation was significantly enhanced following high-frequency stimulation in the GBE50 and EGB761 groups, compared with the model group. These results demonstrate that GBE50 and EGB761 improved the learning and memory of aging rats. In particular, GBE50 administered at the 60 mg/kg dose exhibited superior effects over EGB761 at the same 60 mg/kg dose. Furthermore, the enhancement of hippocampal synaptic plasticity may be an underlying mechanism.The content of total flavonoids in an extract of Ginkgo biloba, called GBE50, is 44% by weight. This is significantly greater than that in a standard extract of Ginkgo biloba, designated EGB761. To date, the mechanisms by which GBE50 and EGB761 function remain poorly understood. In the present study, an experimental rat model of aging was induced by intraperitoneal injection of D-galactose, followed by intragastric perfusion of GBE50 （30, 60 mg/kg）, or EGB761 （60 mg/kg）. The water maze scores and hippocampal CA1 synaptic plasticity were evaluated. In the place navigation test, the GBE50 group rats did better than EGB761, while similar scores were obtained in the spatial probe test, and in the platform-switched test. In addition, long-term potentiation was significantly enhanced following high-frequency stimulation in the GBE50 and EGB761 groups, compared with the model group. These results demonstrate that GBE50 and EGB761 improved the learning and memory of aging rats. In particular, GBE50 administered at the 60 mg/kg dose exhibited superior effects over EGB761 at the same 60 mg/kg dose. Furthermore, the enhancement of hippocampal synaptic plasticity may be an underlying mechanism.

关 键 词：AGING GBE 50 memory impairment HIPPOCAMPUS long-term potentiation neural regeneration 

分 类 号：Q959.837[生物学—动物学] Q427