Synthesis and evaluation of nitrate derivatives of colchicine as anticancer agents  

作　　者：Li Hong Shen Ya Li Da Hai Zhang Yi Sheng Lai Li Jie Liu 

机构地区：[1]Department of Chemistry, Handan College, Handan 056005, China [2]Center of Drug Discover, China Pharmaceutical University, Nanjing 210009, China [3]Hebei Yiling Medicine Corporation Ltd., Shijiazhuang 050035, China

出　　处：《Chinese Chemical Letters》2011年第7期768-770,共3页中国化学快报（英文版）

摘　　要：To search for more potent antitumor agent, a series of novel nitric oxide-donating colchicine （Col） derivatives （6a-f, 8a and b） were synthesized by coupling nitrates with N-methyl colchiceinamide. Their cytotoxicity against four human cancer cell lines in vitro were evaluated by MTT assay. It was found that many of the derivatives displayed significant activity, particularly, compounds 6c, 8a and 8b showed more potent cytotoxic activities than Col.To search for more potent antitumor agent, a series of novel nitric oxide-donating colchicine （Col） derivatives （6a-f, 8a and b） were synthesized by coupling nitrates with N-methyl colchiceinamide. Their cytotoxicity against four human cancer cell lines in vitro were evaluated by MTT assay. It was found that many of the derivatives displayed significant activity, particularly, compounds 6c, 8a and 8b showed more potent cytotoxic activities than Col.

关 键 词：COLCHICINE N-methyl colchiceinamide NITRATES CYTOTOXICITY 

分 类 号：TQ658[化学工程—精细化工] O636.1[理学—高分子化学]