Enantioselective Synthesis of Glutarimide Alkaloids Cordiarimides A, B, Crotonimides A, B, and Julocrotine  

作　　者：滕波 郑剑峰 黄慧英 黄培强 

机构地区：[1]Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China

出　　处：《Chinese Journal of Chemistry》2011年第7期1312-1318,共7页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （No. 20832005） and the National Basic Research Program （973 Program） of China （No. 2010CB833200）.

摘　　要：Five glutarimide alkaloids cordiarimide A （5）, cordiarimide B （6）, crotonimide A （3）, crotonimide B （4）, and julocrotine （2） have been synthesized starting from Boc-L-glutamine （7）. The benzylic alcohol chiral centre of cordiarimides B （6） has been established in 6 ： 1 diastereoselectivity by catalytic asymmetric hydrogenation using Zhou＇s catalytic system Pd（CF3CO2）2/（R,R）-Me-DuPhos.Five glutarimide alkaloids cordiarimide A （5）, cordiarimide B （6）, crotonimide A （3）, crotonimide B （4）, and julocrotine （2） have been synthesized starting from Boc-L-glutamine （7）. The benzylic alcohol chiral centre of cordiarimides B （6） has been established in 6 ： 1 diastereoselectivity by catalytic asymmetric hydrogenation using Zhou＇s catalytic system Pd（CF3CO2）2/（R,R）-Me-DuPhos.

关 键 词：GLUTARIMIDES ALKALOIDS asymmetric hydrogenation DIASTEREOSELECTIVITY enantiostetive synthesis 

分 类 号：O621.34[理学—有机化学] O629.3[理学—化学]