蛋白质翻译起始因子的作用与调控  

Function and Regulation of Protein Translation Initiation Factors

作　　者：郭雷[1] 胡洪[1] 任列娇[1] 高士争[1] 

机构地区：[1]云南农业大学,云南省动物营养与饲料重点实验室,云南昆明650201

出　　处：《云南农业大学学报（自然科学版）》2011年第4期554-559,共6页Journal of Yunnan Agricultural University:Natural Science

基　　金：云南省自然科学基金重点项目(2005C0008Z)

摘　　要：蛋白质翻译起始因子是一类在真核细胞中蛋白质翻译所必需的、保证正确的mRNA-核糖体复合物形成的蛋白质,已知的起始因子共有12种,在真核细胞翻译起始阶段有重要作用。蛋白质合成的调节主要通过翻译起始因子的磷酸化进行。真核细胞蛋白质翻译最重要的调节位点是翻译起始因子eIF-2和eIF-4。本文主要综述了近年来关于蛋白质翻译起始因子的作用及调控的最新研究进展。Eukaryocyte protein translation initiation factors are kinds of proteins required for biosynthesis of proteins in eucaryotic cell and ensured the accurate formation of mRNA-ribosome complex. At present, there are about 12 kinds of eukaryocyte protein translation initiation factors are recognized, they play key role in protein translation initiation. The protein synthesis is mainly regulated by the phosphorylation status of translation initiation factors and the most important regulate factors in eukaryocyte are eIF-2 and eIF-4. In this paper, the progress on the role and regulation of protein translation initiation factors was overviewed.

关 键 词：真核细胞 蛋白质合成 起始因子 

分 类 号：Q753[生物学—分子生物学]