Ki67、PTEN在卵巢浆液性肿瘤中的表达及临床意义  

The Expression and its Clinical Significance of Ki67 and PTEN in Ovarian Serous Tumor

作　　者：邓秀娟[1] 吴海根[2] 

机构地区：[1]南昌大学医学院,在读硕士330006 [2]江西省妇幼保健院妇瘤科,330006

出　　处：《实用癌症杂志》2011年第4期365-367,371,共4页The Practical Journal of Cancer

摘　　要：目的探讨卵巢交界性浆液性囊腺瘤组织中Ki67和PTEN的表达及其意义。方法采用免疫组化SP法,检测32例卵巢交界性浆液性囊腺瘤组织和26例卵巢浆液性囊腺癌组织中Ki67和PTEN表达,并与10例卵巢浆液性囊腺瘤和11例正常卵巢组织进行比较。结果 Ki67和PTEN在卵巢交界性浆液性囊腺瘤组织中阳性表达率分别为65.6%和93.8%,与卵巢浆液性囊腺瘤组织(分别为60.0%和100.%)比较,无统计学意义(P>0.05),而与卵巢浆液性囊腺癌组织比较有统计学意义(P<0.05)。Ⅰ、Ⅱ期卵巢交界性浆液性囊腺瘤患者PTEN阳性表达率,与Ⅲ期患者比较,有统计学意义(P=0.03),而Ⅰ、Ⅱ期卵巢交界性浆液性囊腺瘤患者Ki67阳性表达率,与Ⅲ期患者比较,无统计学意义(P>0.05)。结论 Ki67和PTEN可能在卵巢交界性浆液性囊腺瘤的发生、发展中起重要作用,可能成为卵巢交界性浆液性囊腺瘤预后评价的指标。Objective To explore the expression and its clinical significance of Ki67 and PTEN in ovarian borderline serous adenocarcinoma.Methods Immunohistochemical method was used to determine the expression of Ki67 and PTEN in 32 cases of ovarian borderline serous adenocarcinoma and 26 cases of ovarian serous cystadenocarcinoma,compare with l0 cases of ovarian serous cystadenoma and 11 cases of normal ovarian tissues.Results The positive expression rates of Ki67and PTEN in ovarian borderline serous adenocarcinoma were 65.6%,93.8%,respectively and in ovarian serous cystadenoma were 60.0%,100.0%.there was no significant difference between ovarian borderline serous adenocarcinoma and ovarian serous cystadenoma（P〈0.05） However there was significant between ovarian borderline serous adenocarcinoma and ovarian serous cystadenocarcinoma（P〈0.05）.In ovarian borderline serous adenocarcinoma.the positive expression of PTEN in I-Ⅱstage were significantly higher than Ⅲ stage（P〈0.05）.but the positive expression of Ki67 in Ⅰ-Ⅱstage were no significantly lower than Ⅲ stage（P〉0.05）.Conclusion Ki67 and PTEN may be associated with the occurrence and development of ovarian borderline serous adenocarcinoma and then played an important role in it.As the markers of ovarian borderline serous adenocarcinoma,associated with determination of Ki67 and PTEN will be valuable to estimate the prognosis.

关 键 词：卵巢交界性浆液性囊腺瘤 PTEN基因 KI67基因 

分 类 号：R737.31[医药卫生—肿瘤]