塞莱昔布对化学诱导大鼠乳腺肿瘤病理分级影响的研究  

Celecoxib in the histological grade of chemically induced mammary tumor in rats

作　　者：钱跃清[1] 姚雨石[2] 于忠和[1] 杨光之[3] 战淑君[1] 

机构地区：[1]北京军区总医院肿瘤科,北京100700 [2]北京军区总医院生物治疗中心,北京100700 [3]北京军区总医院病理科,北京100700

出　　处：《中华肿瘤防治杂志》2011年第14期1071-1074,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：首都医学科学发展基金(2002-3025)

摘　　要：目的:评价预防性应用选择性环氧化酶-2(COX-2)抑制剂塞莱昔布对化学诱导大鼠乳腺肿瘤及正常乳腺组织病理分级的影响。方法:雌性SD大鼠予二甲基苯并蒽(DMBA)1次性灌胃诱发乳腺肿瘤过程中,给予不同剂量塞莱昔布,观察肿瘤发生率、数量和体积,并与正常对照组进行病理学分析。结果:与对照组相比,塞莱昔布100和150 mg/kg两剂量组大鼠乳腺肿瘤发生率和肿瘤数量均显著低于模型对照组,但各组间肿瘤平均体积差异无统计学意义,P>0.05。塞莱昔布显著降低大鼠乳腺肿瘤的组织病理分级(100 mg/kg,P=0.021;150 mg/kg,P=0.036),显著降低DMBA导致的乳腺小叶和腺泡的病变程度(100 mg/kg,P=0.004)。结论:预防性应用塞莱昔布具有降低乳腺肿瘤的病理分级,保护正常乳腺组织的作用,其临床应用价值值得进一步探索。OBJECTIVE：To evaluate the impact of celecoxib,a selective cyclooxygenase-2 inhibitor,on the histological grades of chemically induced mammary tumor and normal mammary tissue in rats.METHODS： Single dose of 7,12 dimethlbenz anthracene,DMBA） was administered i.g.into female SD rats to induce mammary tumors,during which various dose levels of celecoxib was dosed.The incidence,number and size of tumor were recorded,and mammary tumors and normal mammary tissues were analyzed via pathological observation.RESULTS： Compared with control group,100 mg/kg and 150 mg/kg celecoxib treatment groups had significantly decreased incidence and number of tumor,while comparable tumor size.More importantly,celecoxib could significantly reduced histopathological grades of both mammary tumors（100 mg/kg,P=0.021;150 mg/kg,P=0.036） and DMBA caused lesions in mammary lobule and alveolus（100 mg/kg,P=0.004）.CONCLUSIONS： Prophylactic administer of celecoxib can reduce pathological grade of chemically induced rat mammary tumor,as well as protecting normal mammary tissues.Its clinical application is worthy of further investigation.

关 键 词：乳腺肿瘤 塞莱昔布 DMBA 大鼠 

分 类 号：R737.9[医药卫生—肿瘤]