重型β-地中海贫血患儿心率变异性的分析  

Heart rate variability in children with beta-thalassemia major

作　　者：马启玲[1] 王波[1] 富国华[1] 陈光福[1] 陈真严[2] 

机构地区：[1]深圳市第二人民医院儿科,广东深圳518035 [2]深圳市第二人民医院心电功能室,广东深圳518035

出　　处：《中国当代儿科杂志》2011年第8期654-656,共3页Chinese Journal of Contemporary Pediatrics

基　　金：深圳市科技局资助项目(201003036)

摘　　要：目的该研究通过对重型β-地中海贫血(β-TM)患儿心率变异性(HRV)的变化特点的研究,探讨HRV对β-TM患儿心功能异常的诊断价值。方法对21例β-TM患儿(地贫组)和15例正常儿童(对照组)分别进行24 h动态心电图(Holter)检查,比较分析两组HRV时域和频域指标的变化及β-TM患儿血清铁蛋白水平与HRV的相关性。结果地贫组患儿HRV时域指标SDNN、rMSSD、pNN50和频域指标极低频谱(VLF)、低频谱(LF)、高频谱(HF)均降低,与对照组比较差异有统计学意义(P<0.05);血清铁蛋白水平与HRV的变化无相关性。结论β-TM患儿自主神经功能异常;HRV对β-TM患儿早期心功能异常有预测价值。Objective To study the diagnostic value of heart rate variability（HRV） in heart dysfunction in children with beta-thalassemia major（β-TM）by examining the changes of HRV in β-TM children. Methods A 24 hours Holter monitoring electrocardiogram（Holter） was performed in 21 children with β-TM and 15 healthy children（control group）.The time domain and frequency domain indexes of HRV in the two groups were compared.The correlation between serum ferritin levels and HRV was evaluated. Results The time domain indexes SDNN,rMSSD and PNN50 and the frequency domain indexes very low frequency（VLF）,low frequency（LF） and high frequency（HF） in the β-TM group were significantly lower than in the control group（P0.05）.There was no correlation between serum ferritin level and HRV in children with β-TM. Conclusions The autonomic nerve dysfunction exists in children with β-TM.HRV analysis is useful in the prediction of early cardiac dysfunction in children with β-TM.

关 键 词：Β-地中海贫血 心率变异性 血清铁蛋白 儿童 

分 类 号：R725.5[医药卫生—儿科]