共轭亚油酸对人胃腺癌细胞的抑制作用  

Inhibitory effect of conjugated linoleic acid on human gastric carcinoma cell line

作　　者：刘家仁[1] 陈炳卿[1] 刘瑞海[2] 路桂芳 朱贇[1] 韩晓辉[3] 

机构地区：[1]哈尔滨医科大学公共卫生学院,哈尔滨150001 [2]CornellUniversity,IthacaNework,U.S.A2 [3]哈尔滨医科大学附属第二医院心外科ICU

出　　处：《卫生研究》1999年第6期353-355,共3页Journal of Hygiene Research

基　　金：国家自然科学基金

摘　　要：采用体外细胞培养方法，研究共轭亚油酸（ＣＬＡ）对人胃腺癌细胞（ＳＧＣ－７９０１）生长的影响。ＣＬＡ的剂量分别为２５、５０、１００和２００μｍ ｏｌ／Ｌ，以乙醇为溶剂对照。结果表明：ＣＬＡ 能抑制ＳＧＣ－７９０１细胞的增殖、细胞核分裂、集落形成和细胞ＤＮＡ的合成。The effects of conjugated linoleic acid(CLA) on human gastric carcinoma cell line(SGC 7901) were studied in cell culture. The four levels of CLA in medium were designed as 25,50,100 and 200μmol/L, and the dissolvent control being ethane. The result displayed that CLA could inhibit the cell proliferation, cellular mitosis, cell clone formation and DNA synthesis and induce cellular differentiation of SGC 7901 cells.

关 键 词：共轭亚油酸 人胃腺癌细胞 抑制 胃癌 

分 类 号：R735.2[医药卫生—肿瘤] R73－36[医药卫生—临床医学]