RhoC和Ki67在非小细胞肺癌中的表达及意义  

Expression and clinical significance of RhoC and ki-67 in non-small-cell lung cancer

作　　者：方长清[1,2] 唐娜[1,2] 杨青松 李淼[4] 王业林[1,2] 李建华[1,2] 

机构地区：[1]中国医科大学附属第一医院病理科 [2]中国医科大学病理教研室,沈阳110001 [3]抚顺市第四医院放射科,抚顺113123 [4]辽宁中医药大学附属第二医院病理科,沈阳110034

出　　处：《中国组织化学与细胞化学杂志》2011年第2期162-165,共4页Chinese Journal of Histochemistry and Cytochemistry

基　　金：辽宁省科学技术厅资助(20082077)

摘　　要：目的探讨RhoC、Ki67在非小细胞肺癌中的表达状况及其与临床病理学参数间的关系。方法利用免疫组织化学(ElivisionTMplus法),检测肺癌组织芯片中151例非小细胞肺癌患者RhoC、Ki67的表达情况。结果肺癌组织的RhoC蛋白阳性表达率为59.60%(90/151),相应癌旁组织RhoC阳性表达率为32.7%(16/49),差别有显著意义(P<0.05)。RhoC在TNMIII/IV期的NSCLC组织中阳性表达率为68.9%(51/74),明显高于在Ⅰ/II期NSCLC组织中阳性表达率50.6%(39/77,P<0.05);RhoC在出现淋巴结转移的表达率为49.2%(32/65),显著高于没有淋巴结转移的阳性表达率67.4%(58/86,P<0.05);非小细胞肺癌中RhoC高表达同Ki-67高表达呈显著正相关关系(χ2=21.634,r=0.377,P<0.01)。结论RhoC的高表达与非小细胞肺癌的分期,淋巴结转移及增殖有关。Objective To explore the expression and significance of RhoC,Ki-67 in non-smallcell lung cancer.Methods The expressions of RhoC and Ki-67 in 151 specimens of lung cancer were detected by immunohistochemistry in tissue microassay.Results The expression of RhoC was detected in 90 of the 151（59.60%） human lung cancer tissues,significantly higher than that in normal lung tissues,which was only in 16 of the 49 cases（32.7%）.The positive expression of RhoC was higher in advanced TNM stages（III＋IV） of NSCLC,than in lower stages（I＋II）（P0.05）.A correlation between RhoC expression and lymph node metastasis was found in our study（P0.05）.Besides,we also found that the overexpression of RhoC was positively correlated with Ki67 in NSCLC（χ2=21.634,r=0.377,P0.01）.Conclusion The overexpression of RhoC is correlated with advanced TNM stage,lymph nodal metastasis and proliferative ability of NSCLC.

关 键 词：RHOC KI67 非小细胞肺癌 侵袭转移 

分 类 号：R743.2[医药卫生—神经病学与精神病学]