肺腺癌CT征象与p53基因缺失表达相关性研究  

Correlation between CT signs and expression of p53 gene deletion in patients with lung adenocarcinoma

作　　者：何苗[1] 关玉宝[1] 曾庆思[1] 顾莹莹[2] 林云恩[2] 陈淮[1] 

机构地区：[1]广州医学院第一附属医院放射科,广东广州510120 [2]广州医学院第一附属医院病理科,广东广州510120

出　　处：《实用医学影像杂志》2011年第4期205-207,共3页Journal of Practical Medical Imaging

基　　金：广东省医学科研基金(A2010237);2008年度广东科技计划项目(83052)

摘　　要：目的探讨肺腺癌CT征象与p53基因缺失率间的关系。方法采用荧光原位杂交技术,检测30例经病理证实的肺腺癌的p53基因缺失情况,并回顾性分析其与术前CT征象间的关系。结果 p53基因缺失率与纵隔淋巴结转移相关(P<0.05),与瘤体大小、深分叶征、短毛刺征、棘状突起、癌性空洞、空泡征、胸膜凹陷征等征象无明显相关性(P>0.05)。结论 p53基因缺失率与肺腺癌的恶性程度呈正相关。Objective To investigate the correlation between CT signs and expression of p53 gene deletion in patients with lung adenocarcinoma.Methods Thirty patients with histopathologically proved lung adenocarcinoma underwent preoperative CT scans of the chest and measurement of p53 gene deletion which was detected by using a fluorescent in situ hybridization technique.Subsequently,the correlation between CT signs and p53 gene deletion was retrospectively analyzed in all patients.Results The study demonstrated that there was significant difference between p53 gene deletion rate and mediastional lymph node metastasis（P0.05）.However,there was not statistical difference between p53 gene deletion rate and CT signs such as deep lobulated,short speculated,acanthoid processes,cancerous cavity,vacuole,and pleural indentation sign（P0.05）.Conclusion There is a positive correlation between p53 gene deletion and malignant grade of lung adenocarcinoma.

关 键 词：P53基因缺失 荧光原位杂交 肺腺癌 体层摄影术 X线计算机 

分 类 号：R734.2[医药卫生—肿瘤]