鲍鱼性腺多糖抗血栓及抗疲劳活性的研究  

Antithrombotic and antifatigue activities of polysaccharide conjugates extracted from abalone gonad

作　　者：郭丽莉[1,2] 朱蓓薇[1,2] 孙黎明[1,2] 牛海铃[1,2] 秦磊[1,2] 刘俊荣[3] 

机构地区：[1]大连工业大学海洋食品教育部工程研究中心,辽宁大连116034 [2]大连工业大学农业部农产品加工技术研发贝类专业分中心,辽宁大连116034 [3]大连海洋大学食品工程学院,辽宁大连116023

出　　处：《大连工业大学学报》2011年第4期250-252,共3页Journal of Dalian Polytechnic University

基　　金：国家高技术研究发展计划(863计划)项目(2011AA100803);科技部农转资金项目(2009GB2B000064);辽宁省重点实验室项目(2008403003);辽宁省教育厅创新团队项目(2009T033;2008T007)

摘　　要：采用大鼠腹主动脉插管放血、体外试管法测定鲍鱼性腺多糖对大鼠血凝块的溶解作用;采用小鼠负重游泳的方法来检测鲍鱼性腺多糖的抗疲劳效果,并对受试小鼠的负重游泳时间、体内糖原、血红蛋白、乳酸及尿素氮含量及乳酸脱氢酶活性等生化指标进行测定。结果表明,鲍鱼性腺多糖(CAGP)具有一定的体外溶栓作用,50和200μg/mL CAGP的溶栓率分别为62.95%和67.70%;CAGP还具有明显的抗疲劳作用,剂量为200 mg/kg时,能显著延长小鼠负重游泳时间,降低血清中乳酸含量,提高组织糖原及血红蛋白含量和乳酸脱氢酶的活力。Effect of CAGP from abalone gonad on resolving blood clot was evaluated by tube method in vitro. The anti-fatigue activity of CAGP on mice was evaluated by loaded-swimming time, glycogen, hemoglobin, lactic acid, urea nitrogen and lactate dehydrogenase level. The results indicated that CAGP could resolve blood clot in vitro, 62.95% and 67.70% of clot-resolving rate were observed at 50 and 200 ug/mL respectively. CAGP could reduce the contents of serum lactic acid, increase the hemoglobin level and activity of the lactate dehydrogenase in serum. The glycogen level both in musculature and hepatic tissue, as well as the swimming time, were also significantly increased.

关 键 词：鲍鱼 鲍鱼性腺多糖 抗血栓 抗疲劳 

分 类 号：TS254.1[轻工技术与工程—水产品加工及贮藏工程] Q53[轻工技术与工程—食品科学与工程]