多羟基苯甲醛席夫碱的抗氧化性能研究  

The Study of Antioxidant Activity of Polyhydroxy Benzaldehyde Schiff Bases

作　　者：梁学锋[1] 黄美欣[1] 周博[1] 郑挺[1] 黄时绵[1] 闫素君[1] 马林[1] 

机构地区：[1]中山大学化学与化学工程学院,广东广州510275

出　　处：《广东化工》2011年第8期1-2,7,共3页Guangdong Chemical Industry

基　　金：中山大学实验室开放基金项目(KF201027);暨南大学广东省生物工程药物重点实验室开放基金资助项目

摘　　要：微波辅助法快速合成26个多羟基苯甲醛席夫碱系列化合物,并从清除羟基自由基和DPPH自由基能力两方面研究了该系列化合物的体外抗氧化活性。结果表明,该系列化合物对上述两种自由基均有较好的清除效果,其中清除羟基自由基的EC50值介于23～187μmol/L,清除率为27.54%～237.2%,清除效果比Vc强;而清除DPPH自由基的EC50值介于6.7～7.2μmol/L,清除率处于58.0%～69.1%之间,过半测试化合物的清除能力强于Vc。After microwave assisted rapid synthesis of more than 26 hydroxyl benzaldehyde Schiff bases, we test their capacity of scavenging DPPH and OH radical which helped us study on the vitro antioxidant activity of these series of compounds. The results showed that the compounds had good scavenging effect on the two radical. Compared with Vc, most of compounds had seacenged the hydroxyl radical more completely with ECs0 between 23-187 0rnoUL, and SA between 27.54 %-237.2 %, while about half of them have as good scavenging capacity of the DPPH radical as the Vc has, with EC50 between 6.7,--47.2 μmol/L and SA between 58.0 %-69.1%.

关 键 词：多羟基苯甲醛席夫碱 抗氧化性 羟基自由基 DPPH自由基 

分 类 号：TQ244.1[化学工程—有机化工]