2-氯-5-硝基嘧啶的合成  

Synthesis of 2-Chloro-5-nitropyrimidine

作　　者：贾云宏[1] 谢洪磊[1] 蔡东[1] 张丽华 

机构地区：[1]辽宁医学院药学院,辽宁锦州121001 [2]东昌府中医院,山东聊城252000

出　　处：《农药》2011年第9期641-642,共2页Agrochemicals

摘　　要：[方法]以1,1,3,3-四甲氧基丙烷和尿素为起始原料,通过合环、硝化和氯代反应得到2-氯-5-硝基嘧啶,探讨了合成关键中间体的影响因素。[结果]经过实验确定了理想的反应条件,产物的结构经过1H NMR鉴定进行表征。[结论]该工艺具有收率高、操作简单、安全可靠的特点并且为工业化生产提供参考。[Methods] 1,1,3,3-Tetramethoxypropane and urea were used as starting material to give the 2-chloro-5- nitropyrimidine by cyclization, nitration and chlorination. The effect factors synthesizing the key intermediate were discussed. [Results] The ideal conditions were determined by experiments, and their structures were confirmed by 1↑H NMR. [Conclusions] The synthetic process has advantages of high yield, simple operation and safety and is important directive to industrialized production.

关 键 词：尿素 2-氯-5-硝基嘧啶 合成 

分 类 号：TQ453.2[化学工程—农药化工]