Chiral Phosphoric Acid Catalyzed Enantioselective Allylation of Aldehydes with Allyltrichlorosilane  

作　　者：程柯 范甜甜 孙健 

机构地区：[1]Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, China [2]Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, Sichuan 610041, China

出　　处：《Chinese Journal of Chemistry》2011年第8期1669-1671,共3页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （Nos. 20732006 and 20972152）.

摘　　要：Easily accessible chiral phosphoric acid lb has been applied as efficient organocatalyst for the asymmetric al- lylation of aldehydes with allyltrichlorosilane. In the presence of 20 mol% of lb, the allylation of a broad range of aldehydes proceeded smoothly to give the corresponding homoallylic alcohol with up to 87% ee and 97% yield.Easily accessible chiral phosphoric acid lb has been applied as efficient organocatalyst for the asymmetric al- lylation of aldehydes with allyltrichlorosilane. In the presence of 20 mol% of lb, the allylation of a broad range of aldehydes proceeded smoothly to give the corresponding homoallylic alcohol with up to 87% ee and 97% yield.

关 键 词：phosphoric acid ALLYLATION ALDEHYDES ALLYLTRICHLOROSILANE 

分 类 号：O623.412.1[理学—有机化学] O643.36[理学—化学]