复合微量营养素补充剂对北京市成人血和尿营养素水平的影响  

Impact of multinutrient supplements on adult nutrient status in blood and urine in Beijing

作　　者：李可基[1] 元香南[1] 杜芳伟 Yumei LIN Mei LI 黄晓明 Randolph R. Keith 

机构地区：[1]北京大学公共卫生学院营养与食品卫生系,100191 [2]安利（中国）研发中心,北京100191 [3]美国纽崔莱健康研究所,广州510730

出　　处：《中华临床营养杂志》2011年第4期227-231,共5页Chinese Journal of Clinical Nutrition

摘　　要：目的探讨复合微量营养素补充剂对健康成人体内营养素水平的影响。方法选择北京市152名推荐食谱问卷得分低于12分的健康成年人作为研究对象，采用随机数字表法分为安慰剂组和补充剂组，每组76名。两组分别服用安慰剂和复合微量营养素补充剂。8周后检测受试者血浆及尿液中营养素浓度的变化情况。并于研究第56天同时给两组受试者服用复合微量营养素补充剂，观察服药前和服药后2 h血浆营养素水平变化。结果安慰剂组有3例失访，失访率为5.7%。服用复合微量营养素补充剂8周后，补充剂组的血浆α-生育酚［（18.23±0.82）比（14.55±0.73）μmol/L］、β-胡萝卜素［（4.28±0.29）比（2.38±0.24）μmol/L］、维生素C［（42.65±2.11）比（27.49±1.76）μmol/L］、B6［（323.51±15.88）比（69.43±10.47）nmol/L］和B12浓度［（1005.27±23.00）比（796.85±35.57）pmol/L］，尿维生素B1［（899.24±70.73）比（174.42±13.38）μg/g·Cr］和B2水平［（3227.68±330.04）比（259.10±33.33）μg/g·Cr］，及红细胞叶酸水平［（720.09±21.33）比（633.17±28.75）nmol/L］均明显高于安慰剂组（P均=0.0000），血浆γ-生育酚浓度明显低于安慰剂组［（2.18±0.13）比（2.87±0.26）μmol/L，P=0.0001］。服用复合微量营养素补充剂2 h后，补充剂组的血浆维生素C水平明显高于安慰剂组［（54.53±2.43）比（23.02±1.77）μmol/L，P=0.0000］。结论服用复合微量营养素补充剂可改变健康成人体内的营养素水平，但其意义有待进一步研究探讨。ObjectiveTo determine the impact of multinutrient supplements on adult nutrient status in Beijing, China. MethodsIn this randomized, double-blind, and placebo controlled trial, 152 healthy adults with a Recommended Food Score lower than 12 were equally and randomly divided into multinutrient supplement group and placebo group. Plasma and urine nutrient levels including vitamin A, B1, B2, B6, B12, C, folate, α- and γ-tocopherol, and carotenoids were determined before and after 8-week intervention. Acute response on vitamin C, carotenoids and tocopherols status were also determined on day 56. ResultsThree cases （5.7%） were lost to follow-up in placebo group. Compared with the placebo group, α-tocopherol[（18.23±0.82） vs.（14.55±0.73）μmol/L], β-carotene[（4.28±0.29） vs.（2.38±0.24）μmol/L], vitamin C[（42.65±2.11） vs.（27.49±1.76）μmol/L], B6 [（323.51±15.88） vs.（69.43±10.47）nmol/L] and B12 [（1005.27±23.00） vs.（796.85±35.57）pmol/L] levels in plasma, B1 [（899.24±70.73） vs.（174.42±13.38）μg/g·Cr] and B2 [（3227.68±330.04） vs.（259.10±33.33）μg/g·Cr] levels in urine, and folate level in red blood cells [（720.09±21.33） vs.（633.17±28.75）nmol/L] significantly increased after 8 weeks of intervention （all P=0.0000）, while plasma γ-tocopherol level significantly decreased [（2.18±0.13） vs.（2.87±0.26）μmol/L, P=0.0001]. Significant acute response on vitamin C was also observed in the multinutrient supplement group[（54.53±2.43） vs.（23.02±1.77）μmol/L, P=0.0000]. ConclusionThis multinutrient supplement can effectively improve the nutrient status of healthy Chinese adults.

关 键 词：复合微量营养素补充剂 营养素 中国成人 

分 类 号：R151[医药卫生—营养与食品卫生学]