5-hydroxytryptamine-mediated apnea caused by the habenular nucleus  

作　　者：Min Wang Weihong Lin Jinghua Wang Min Huang Chunyong Wang Mingxian Li Shao Wang 

机构地区：[1]Department of Pneumology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China [2]Department of Neurology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China [3]Department of Physiology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, Jilin Province, China [4]School of Public Health, Jilin University, Changchun 130021, Jilin Province, China

出　　处：《Neural Regeneration Research》2011年第20期1554-1558,共5页中国神经再生研究（英文版）

基　　金：the National Natural Science Foundation of China, No. 30270502

摘　　要：5-hydroxytryptamine contributes to the control of activities of the dilator muscle in the upper respiratory tract, and is derived from the raphe nuclei, in which the habenular nucleus exerts a sustaJned inhibitory effect. In the present study, respiratory motion curve of the genJoglossus muscle and peripheral 5-hydroxytryptamine changes were observed following L-glutamate stimulation of the habenular nucleus of adult Wistar rats. Results showed that the rats had apnea and decreased plasma 5-hydroxytryptamine content after the neurons in habenular nucleus were excited. Genioglossus muscle electromyogram amplitude and integral were significantly reduced. The genioglossus myoelectric activity and respiratory motion curve were similar to obstructive sleep apnea syndrome, thus confirming that the habenular nucleus is the key nucleus involved in the pathogenesis of obstructive sleep apnea syndrome, and is the primary regulated center in the raphe nuclei. Stimulation of the habenular nucleus may suppress 5-hydroxytryptamine release and result in apnea, which is similar to obstructive sleep apnea syndrome.5-hydroxytryptamine contributes to the control of activities of the dilator muscle in the upper respiratory tract, and is derived from the raphe nuclei, in which the habenular nucleus exerts a sustaJned inhibitory effect. In the present study, respiratory motion curve of the genJoglossus muscle and peripheral 5-hydroxytryptamine changes were observed following L-glutamate stimulation of the habenular nucleus of adult Wistar rats. Results showed that the rats had apnea and decreased plasma 5-hydroxytryptamine content after the neurons in habenular nucleus were excited. Genioglossus muscle electromyogram amplitude and integral were significantly reduced. The genioglossus myoelectric activity and respiratory motion curve were similar to obstructive sleep apnea syndrome, thus confirming that the habenular nucleus is the key nucleus involved in the pathogenesis of obstructive sleep apnea syndrome, and is the primary regulated center in the raphe nuclei. Stimulation of the habenular nucleus may suppress 5-hydroxytryptamine release and result in apnea, which is similar to obstructive sleep apnea syndrome.

关 键 词：SLEEP APNEA habenular nucleus 5-HYDROXYTRYPTAMINE GENIOGLOSSUS neural electrophysiology neural regeneration 

分 类 号：Q424[生物学—神经生物学] X51[生物学—生理学]