This study was supported by grants from the National Natural Science Foundation of China (No. 81271192 and No. 81600897), and the Shanghai Science and Technology Committee of China (No. 15140903500).
Background: Chronic intermittent hypoxia is the most remarkable feature of obstructive sleep apnea/hypopnea syndrome and it can induce the change of hypoxia-inducible factor-1α (H IF-1α) expression and contractil...
supported by the Social Development of Science and Technology Program of Ningbo City(No.2010C50031);the Ningbo Natural Science Foundation(No.2013A610261),China
Objective: To evaluate the effect of pharyngeal musculature and genioglossus exercising on obstructive sleep apnea and hypopnea syndrome (OSAHS). Methods: We conducted a non-randomized retrospective clinical trial...
Background: The suitability of micro-computed tomography (CT) for soft tissue applications has been well documented. Although the application of micro-CT to the three dimensional (3D) structure of the tongue muscle ha...
This study was supported by grants from the National Natural Science Foundation of China (No. 81270145) and Clinical Respiratory Research Center of Jiangsu Province (BL2012012).
Background Obstructive sleep apnea hypopnea syndrome, characterized by chronic intermittent hypoxia (CIH), is closely correlated with genioglossus dysfunction. CIH has been identified to mediate mitochondrial damage...
Background Genioglossal dysfuntion takes an important role in pathogenesis of obstructive sleep apnea hypopnea syndrome (OSAHS) in which chronic intermittent hypoxia (CIH) is the major pathological origin. Recent ...
the National Natural Science Foundation of China, No. 30270502
5-hydroxytryptamine contributes to the control of activities of the dilator muscle in the upper respiratory tract, and is derived from the raphe nuclei, in which the habenular nucleus exerts a sustaJned inhibitory eff...
the National Natural Science Foundation of China,No.V30270502,C010703
BACKGROUND: The insular cortex and habenular nucleus may be a regulatory center for obstructive sleep apnea syndrome, and dyspnea may be caused by insular cortex activity. The insular cortex is a cortical representat...
This work was supported by the National Natural Science Foundation of China (No. 30670920), Beijing Municipal Natural Science Foundation of China (No. 7072079).
Background 5-hydroxytryptamine (5-HT) is a common neurotransmitter in the brain which plays an important role in the pathogenesis of sleep apnea.Dysfunction of 5-HT and 5-HT2 receptors may lead to the collapse of th...
This study was supported by grants from National Natural Science Foundation of China (No.30770954 and No.30971167) and Social Development Project of Changzhou (No.CS20092016).
Background The genioglossus (GG) is involved in the maintenance of an open airway for effective breathing.Although the pathogenesis of obstructive sleep apnea hypopnea syndrome (OSAHS) was closely associated with ...