Correlation between heart rate variability and pupillary reflex in healthy adult subjects under the influence of alcohol  

作　　者：Jin Ma Rumeng Ma Xiwen Liu Zhihong Wen Xiaojing Li Tao Wang Wenqiang Han Wendong Hu Zuoming Zhang 

机构地区：[1]Department of Aerospace Medical Equipment, Faculty of Aerospace Medicine, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China [2]Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, Shaanxi Province, China [3]Department of Basic Nursing, Nursing School, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China [4]School of Humanities and Science of Xi'an Jiaotong University, Xi'an 710032, Shaanxi Province, China [5]Department of Clinical Aerospace Medicine, Faculty of Aerospace Medicine, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China

出　　处：《Neural Regeneration Research》2011年第21期1646-1650,共5页中国神经再生研究（英文版）

基　　金：the National Natural Science Foundation of China, No.60879007

摘　　要：This study explored the association between pupil area variation, heart rate variability, and fatigue, caused by alcohol consumption. Sixteen healthy young male volunteers were enrolled in this study for a series of structured physical examinations. Individual drinking volume was strictly assessed in accordance with the normalized experimental design. The motions of the subjects＇ pupils, as well as electrocardiograms were recorded by a computerized recording system, both before and after drinking alcohol. After alcohol intake, the pupil diameter, and both low frequency and standard deviation of all heartbeat interval indices of heart rate variability showed significant variations compared with the baseline. In addition, time- and frequency-domain indices of heart rate variability were negatively associated with pupil area. Thus the current study suggests that fatigue status may be determined by significant changes in pupil area and heart rate variability.This study explored the association between pupil area variation, heart rate variability, and fatigue, caused by alcohol consumption. Sixteen healthy young male volunteers were enrolled in this study for a series of structured physical examinations. Individual drinking volume was strictly assessed in accordance with the normalized experimental design. The motions of the subjects＇ pupils, as well as electrocardiograms were recorded by a computerized recording system, both before and after drinking alcohol. After alcohol intake, the pupil diameter, and both low frequency and standard deviation of all heartbeat interval indices of heart rate variability showed significant variations compared with the baseline. In addition, time- and frequency-domain indices of heart rate variability were negatively associated with pupil area. Thus the current study suggests that fatigue status may be determined by significant changes in pupil area and heart rate variability.

关 键 词：ALCOHOL heart rate variability pupillary measure FATIGUE 

分 类 号：TS262.2[轻工技术与工程—发酵工程] U491.254[轻工技术与工程—食品科学与工程]