玫瑰花茶对束缚应激小鼠旷场活动性的影响  

Effect of the rose extract on stressed mice in open-field test

作　　者：陈文[1] 任超[1] 刘娇[1] 王祎[1] 郭月逸[1] 

机构地区：[1]北京联合大学应用文理学院北京市生物活性物质与功能食品重点实验室,北京100191

出　　处：《食品工业科技》2011年第9期396-398,共3页Science and Technology of Food Industry

基　　金：北京联合大学自然科学类项目(2009)

摘　　要：旨在探讨玫瑰花茶对束缚应激小鼠自主探究活动能力的影响。将8周龄雄性BALB/C小鼠分为4组:正常对照组(C组)、应激对照组(S组)、低剂量玫瑰花茶组(L-RE组)、高剂量玫瑰花茶组(H-RE组)。S、L-RE、H-RE组小鼠每日给与1h的束缚刺激,30min后分别灌喂水和相应剂量的玫瑰花茶。连续6周后用Smart小动物行为活动记录分析系统进行旷场实验。结果显示,S组小鼠在旷场周边区域、中央区域的活动性分别比C组小鼠减弱了10.8%(P<0.05)和15.7%,快速移动时间百分率显著降低(P<0.05)。与S组相比较,L-RE组小鼠在旷场周边区域、中央区域的探究活动性明显提升(P<0.05),不动时间百分率下降(P<0.05);H-RE组小鼠在周边区的探究活动性提高(P<0.05),不动时间百分率下降(P<0.05)。以上结果显示玫瑰花茶能够缩短束缚应激小鼠的不动时间,提高小鼠在旷场中央和周边区域的自主探究活动能力,起到缓解应激小鼠焦虑状态的作用。In order to study the effect of rose extract on the open-field test of stressed mice,8-weeks-old male BALB/C mice were divided into 4 groups：control group（C）,stressed group（S）,low-dose rose extract group（L-RE）,and high-dose rose extract group（H-RE）based on their body weights.The mice of S,L-RE and H-RE group were suffered restraint stress 1h a day.6 weeks later,open-field test was determined.Results showed that compared with C group,fast-moving time（%）and the locomotive activity of S group in periphery and central area were markedly decreased（P0.05）.Compared with S group,L-RE group had higher locomotive activity in periphery and central area and had less immobility time（%）（P0.05）,and H-RE group had higher locomotive activity in periphery area and less immobility time（%）（P0.05）.The above results suggested rose extract was reducing the immobility time and improving the locomotive activity of stressed mice and showed some anxiolytic effect.

关 键 词：玫瑰花 旷场 束缚应激 小鼠 

分 类 号：TS201.4[轻工技术与工程—食品科学]