SAMP8鼠血小板线粒体超微结构的增年龄性变化  

Aging-related changes in the ultrastructure of platelets in SAMP8 mice

作　　者：石纯[1] 武凤鸣[1] 徐杰[2] 郭开华[1] 

机构地区：[1]广州医学院人体解剖学教研室,广东广州510260 [2]中山大学中山医学院人体解剖学教研室

出　　处：《解剖学研究》2011年第4期262-264,共3页Anatomy Research

摘　　要：目的观察不同月龄SAMP8鼠(快速老化鼠P8)血小板线粒体超微结构的变化。方法提取2、6及9月龄SAMP8鼠的血小板并进行电镜观察。结果随月龄的增加,SAMP8鼠血小板线粒体退变逐渐明显。9月龄SAMP8鼠的血小板线粒体呈明显的退行性变。结论 SAMP8鼠血小板线粒体超微结构呈增龄性改变,提示线粒体变性可能是SAMP8鼠快速老化的机制之一。血小板可广泛地用于研究线粒体机能和老化相关疾病。Objective To observe the changes in the ultrastructure of platelets in different age groups of SAMP8 mice.Methods Mitochondria were isolated from platelets in 2,6 and 9 month-old SAMP8 mice and the ultrastructure of platelet mitochondria was observed using transmission electron microscopy.Results platelet mitochondria in SAMP8 mice displayed morphological abnormality,which exacerbated in extent with age.SAMP8 mice at 9 months of age showed obvious mitochondrial abnormality.Conclusion Mitochondrial degeneration might be one of the mechanisms leading to age-associated degeneration in SAMP mice at an early age and the platelets could serve as a biomarker for detection of mitochondrial function and age related disease.

关 键 词：快速专化P8 血小板 线粒体 老化 

分 类 号：R363[医药卫生—病理学]