一种新型手性席夫碱和手性β-氨基醇配体的合成  

A convenient synthesis of novel chiral Schiff base and β-amino alcohol ligands

作　　者：李俊奇[1] 乔治国[1] 崔付娜[1] 宋庆宝[1] 

机构地区：[1]浙江工业大学化学工程与材料学院,浙江杭州310032

出　　处：《浙江工业大学学报》2011年第5期508-510,共3页Journal of Zhejiang University of Technology

基　　金：浙江省应用化学重中之重学科开放基金资助项目(20050506)

摘　　要：手性席夫碱和手性β-氨基醇是近年来关注较多且在不对称催化反应中具有很大发展潜力的优秀配体或催化剂.以天然L-苯丙氨酸为起始原料,经简单的两步反应生成手性β-氨基醇Ⅲ,再与实验室自制二茂铁羰基化合物Ⅳ在室温下于二氯甲烷溶剂中反应,高产率(93.1%)生成新型手性席夫碱配体Ⅴ,该手性席夫碱配体经三倍当量的硼氢化钠还原生成二茂铁修饰的手性β-氨基醇Ⅵ.化合物Ⅴ和Ⅵ都未见文献报道.产物及中间体结构均经IR,1 H NMR和MS表征确认.Chiral Schiff bases and chiral β-amino alcohols have attracted more attention in recent years. They are excellent ligands or catalysts which have great potential in asymmetric catalytic reactions, β-amino alcohol Ⅲ was synthesized from L-phenylalanine in two simple steps. The novel chiral Schiff base ligand V was achieved easily in high yield （93.1%） with compound three and a laboratory made compound IV at room temperature in dichloromethane. The ferrocene- based chira1 β-amino alcohol Ⅵ was prepared by reducing the chiral Schiff base ligand V with Ⅲ equivalent NaBH4. Compounds Vand Ⅵ have not been reported in literatures. The structures of products and intermediates were confirmed by IR, 1H NMR and MS spectra.

关 键 词：手性配体 席夫碱 Β-氨基醇 二茂铁 

分 类 号：TQ226.34[化学工程—有机化工]