3,5-二碘水杨醛缩水杨酰肼Schiff碱及其金属配合物的合成与抑菌活性  

Synthesis and Antibacterial Activity of Its Metal Complexes of Salicyhydrazide and 3,5-Diiodo-salicylalidehyde Schiff Base

作　　者：高敏[1] 杨天林[1] 马志强[1] 张晶晶[1] 

机构地区：[1]宁夏大学能源化工重点实验室,化学化工学院,银川750021

出　　处：《应用化学》2011年第10期1167-1172,共6页Chinese Journal of Applied Chemistry

基　　金：教育部科学技术研究重点基金(208195);甘肃省有色金属化学与资源利用重点实验室开放课题基金资助项目

摘　　要：以吡啶、DMF为溶剂合成了3,5-二碘水杨醛缩水杨酰肼Schiff碱的过渡金属配合物,用紫外可见光谱、红外光谱、TG-DTA、元素分析及摩尔电导率对配合物进行了表征,推测了配合物的可能结构,并对结构特征进行了分析。应用紫外光谱和荧光光谱测定方法研究了配合物与ct-DNA的作用,发现这些配合物均以插入方式与ct-DNA作用。另外,对各配合物作了活性测试,发现它们对阴离子超氧自由基O2-.和藤黄微球菌有良好的抑制作用。Four coordination compounds of transition metal with 3,5-diiodo-salicylalidehyde and salicyhydrazide Schiff base have been synthesized in pyridine and DMF solvents.These ligand and complexes were characterized by UV and IR spectra,TG-DTG,elemental analysis,and molar conductance analysis.The interactions of the complexes with DNA were investigated by UV and fluorescence spectroscopies,which show that the binding mode of the complexes with ct-DNA was intercalation.In addition,the biological activity test reveals that the complexes have potentially catalytic and antibacterial activity towards superoxide anion radical O-·2 and Micrococcus luteus.

关 键 词：含碘Schiff碱 过渡金属配合物 光谱性质 抑菌活性 

分 类 号：O611.6[理学—无机化学]