Glut1与Ki-67在结直肠癌中的表达及其与^(18)F-FDG PET/CT SUV_(max)的相关性  

Expression of Glut1 and Ki-67 of colorectal cancer and its correlation with SUV_(max) in ^(18)F-FDG PET/CT

作　　者：李迎辞[1] 于丽娟[1] 田墨涵[1] 王大龙[1] 王文志[1] 

机构地区：[1]哈尔滨医科大学附属第三医院PET/CT中心,黑龙江哈尔滨150081

出　　处：《中国医学影像技术》2011年第9期1855-1858,共4页Chinese Journal of Medical Imaging Technology

基　　金：黑龙江省自然科学基金(D200863)

摘　　要：目的探讨葡萄糖转运蛋白1(Glut1)与细胞增殖抗原标记物Ki-67在结直肠癌(CRC)中的表达及其与18F-FDG PET/CT显像最大标准摄取值(SUVmax)的关系。方法对33例经术后病理证实的CRC患者术前进行全身PET/CT检查,记录病灶的SUVmax,用免疫组化方法分析Glut1、Ki-67表达,并与SUVmax进行对比分析。结果 Glut1和Ki-67在CRC中的表达均高于正常组织(t=-4.22、-3.04,P均<0.05)。Glut1在CRC中的阳性表达率显著高于正常组织(χ2=18.94,P<0.05),在低分化CRC中的阳性表达率(5/7,71.42%)高于中-低分化(1/3,33.33%)和中分化(16/23,69.57%)CRC。CRC的SUVmax与Glut1的表达存在相关性(r=0.63,P<0.05),与Ki-67无相关性(r=0.24,P=0.36)。不同分化程度CRC的SUVmax之间差异无统计学意义(F=0.54,P=0.59);不同肉眼大体分型CRC的SUVmax之间差异无统计学意义(t=-0.07,P=0.95)。结论 Ki-67可反映CRC细胞的增殖状态;CRC的SUVmax可反映CRC组织中Glut1的表达水平。Objective To explore the expression of glucose transporter 1（Glut1） and Ki-67 of colorectal cancer（CRC） and it＇s correlation with maximum standard uptake value（SUVmax） in 18F-FDG PET/CT.Methods Thirty-three patients with CRC proved by postoperative pathology underwent PET/CT imaging preoperatively,and SUVmax of lesions were recorded.The expression of Glut1 and Ki-67 were analyzed by immunohistochemistry,and compared with SUVmax.Results The expression of Glut1 and Ki-67 in CRC were higher than that in normal tissue（t=-4.22,-3.04,both P0.05）.The positive expression of Glut1 in CRC tissue was remarkably higher than in normal tissue（χ2=18.94,P0.05）.The positive expression of Glut1 in poorly differentiated CRC（5/7,71.42%） was higher than that in the moderately-poorly CRC（1/3,33.33%） and moderately differentiated CRC（16/23,69.57%）.There was correlation between CRC＇s SUVmax and Glut1 expression（r=0.63,P0.05）,but not between CRC＇s SUVmax and Ki-67（r=0.24,P=0.36）.There was no statistical different among different differentiation CRC＇s SUVmax（F=0.54,P=0.59）,nor among different morphologic CRC＇s SUVmax（t=-0.07,P=0.95）.Conclusion Ki-67 can reflect the proliferation level of CRC cells,and SUVmax can reflect the expression level of Glut1 in CRC.

关 键 词：结直肠肿瘤 18F氟脱氧葡萄糖 正电子发射型体层摄影术 体层摄影术 X线计算机 GLUT1 KI-67 

分 类 号：R735.3[医药卫生—肿瘤] R817.4[医药卫生—临床医学]