首发未服药精神分裂症患者脑弥散张量成像的基于体素分析  被引量:6

A voxel-based diffusion tensor imaging study of first-episode medication-free patients with schizophrenia

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作  者:魏钦令[1] 郑俩荣[1] 胡冰[2] 康庄[2] 国效锋[3] 胡茂荣[3] 韩自力[1] 

机构地区:[1]中山大学附属第三医院精神科,广州510630 [2]中山大学附属第三医院放射科,广州510630 [3]中南大学湘雅二医院精神卫生研究所,长沙410011

出  处:《中华神经医学杂志》2011年第9期926-928,共3页Chinese Journal of Neuromedicine

基  金:基金项目:2010年卫生行业科研专项(201002003);国家自然科学基金青年项目(30900485);广东省自然科学基金(9151008901000065)

摘  要:目的分析首发未服药精神分裂症患者脑白质完整性的变化。方法对40例首发未服药精神分裂症患者和68例健康对照者进行脑弥散张量磁共振成像检查,以DTI-studio软件和统计参数图(SPM)软件对所得图像进行预处理,得到的各向异性分数(FA)图像在SPM软件中进行两样本t检验.获得两组患者FA值差异统计参数图。结果在P值小于0.001(未校正)水平下。首发未服药精神分裂症患者右侧杏仁核区(MNI:24,2,-14,cluster=347voxels)、双侧前扣带区(MNI:6,42,2,cluster=586voxels)、右侧前额叶眶上回区域(MNI:20,18,-10,cluster=166voxels)白质FA值较健康对照者下降,且未发现前者有脑区白质FA值较后者增高。结论精神分裂症患者皮层一边缘系统环路存在结构连接障碍,这可能是精神分裂症的神经机制。Objective To explore the changes of white matter integrity in first-episode medication-free patients with schizophrenia. Methods Diffusion tensor images (DTI) of whole brains of 40 first-episode medication-free patients with schizophrenia and 68 healthy controls were acquired with a single-shot echo planar imaging (EPI) sequence aligned to the straight axial plane. Two-sample t-test by with voxel-based analysis in SPM5 sottware was performed on the fractional anisotropy (FA) images of the 2 groups after being preprocessed with DTI-studio and SPM5 software. Results Subjects of schizophrenia showed reduced white matter FA in these regions: the right amygdale (MNI: 24, 2, -14; cluster=347 voxels), bilateral anterior cingulate (MNI: 6, 42, 2; cluster=586 voxels), right orbitofrontal (MNI: 20, 18, -10; cluster=166 voxels) as compared with healthy controls. Conclusion Abnormal white matter in the corticolimbic system circuit exists in patients with schizophrenia, which maybe involve in the neural mechanism of schizophrenia.

关 键 词:精神分裂症 白质 弥散张量成像 基于体素分析 

分 类 号:R749.3[医药卫生—神经病学与精神病学]

 

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