肿瘤患者对新药临床试验的认知度与接受度调查  

Attitudes of Patients to New Drug Clinical Trials of Cancer Therapy

作　　者：曹烨[1] 高文超[2] 郑上游[2] 陈楚杰[2] 陈金瓯[3] 陈婉玲[2] 李海波[2] 吴春燕[2] 杨洪生[2] 罗懿琦[2] 陈欣[2] 洪明晃[1] 

机构地区：[1]华南肿瘤学国家重点实验室,中山大学肿瘤防治中心临床试验研究中心,药物临床试验机构,广东广州510060 [2]中山大学中山医学院,广东广州510080 [3]中山大学中山医学院公共卫生学院,广东广州510080

出　　处：《中国肿瘤》2011年第9期659-664,共6页China Cancer

摘　　要：[目的]了解肿瘤患者对新药临床试验的认知度和接受度现状。[方法]根据患者是否参与过临床试验,分别设计两份"肿瘤患者对临床试验的认知度和接受度"调查问卷,并于2010年8月～10月期间在中山大学肿瘤防治中心门诊和住院开展调查,共403名患者及家属完整回答问卷,并当场回收,随后统计分析。[结果]370名未参与过临床试验的肿瘤患者对临床试验的认知度和接受度普遍较低,甚至存在偏见和误解;但参加过临床试验的33名患者比从未参加的患者在认知度方面有所提高,但仍然对"随机"、"安慰剂"等概念认识模糊;接受度方面,78.5%的受调查者认为肿瘤临床试验对促进肿瘤研究及改善疗效有重要意义,大部分病人(75.8%)在结束临床试验后愿意将血液或者其它标本用于其它研究。[结论]目前我国肿瘤患者对临床试验的认知度和接受度均低,有待进一步提高。提高医护人员对临床试验的认知度和接受度是提高病患认知水平的重要途径;另外,加强网络、报刊等媒体宣传也是提高公众正确认识新药临床试验的关键。[Purpose] To investigate the cancer patients＇ cognition and acceptance for anticancer drug clinical trials. [Methods] Two questionnaires were designed respectively based on whether or not the patients have been enrolled before clinical trials. From August to October in 2010, 403 patients who attended the outpatient department or admitted in Cancer Center, Sun Yat-sen University had been surveyed successfully. All the data were collected and analyzed then. [Results] Low cognition and poor acceptance regarded to clinical trials in 370 patients who did not enroll the trials; some of them even had some bias and misunderstanding. Among the trials-enrolled patients, the recognition for some concepts, like randomization, placebo, were still vague, though their cognition and acceptance were better than the former. 78.5% cancer patients considered that clinical trials had remarkable contribution to cancer research and quality of health care. 75.8% respondents showed their wills to donate their blood or tissue samples for future studies. [Conclusions] The current cognition and acceptance for clinical trials among cancer patients still need to be improved. Improving medical staff＇s education for clinical trials is the primary approach and is essential for the pharmaceutical research. In addition, public media should be involved as an assistant.

关 键 词：肿瘤 临床试验 认知度 接受度 

分 类 号：R730.1[医药卫生—肿瘤]