进行性肌阵挛癫痫患者口服苯妥英钠致非惊厥性癫痫持续状态  

Non-convulsive status epilepticus induced by oral phenytoin in a patient with progressive myoclonic epilepsy

作　　者：高乐虹[1] 

机构地区：[1]首都医科大学宣武医院神经内科,北京100053

出　　处：《药物不良反应杂志》2011年第4期255-256,共2页Adverse Drug Reactions Journal

摘　　要：1例16岁女性进行性肌阵挛癫痫患者,口服苯妥英钠0.15 g、1次/12 h治疗1周后出现非惊厥性癫痫持续状态,脑电图呈全导持续性棘慢波节律。7周后入我院,立即将苯妥英钠减量至0.05 g,2次/d,2 d后停用,同时给予患者丙戊酸钠0.3 g,1次/8 h;氯硝西泮1 mg,1次/12 h;左乙拉西坦0.25 g,1次/12 h。治疗第3天患者肌阵挛发作消失,治疗第6天脑电图示散在棘慢波、慢波,住院12 d,病情平稳出院。A 16-year-old female patient with progressive myoclonic epilepsy developed non-convulsive status epilepticus after receiving oral phenytoin 0.15 g every 12 hours for one week.An EEG showed continuous spike-and-slow-wave complexes in all leads. Seven weeks after that,the patient was admitted to our hospital,her phenytoin dosage was reduced to 0.05 g twice daily at once and then withdrawn 2 days later.At the same time,the patient was given sodium valproate 0.3 g every 8 hours;clonazepam 1mg every 12 hours; levetiracetam 0.25 g every 12 hours.On day 3 of treatment,the patient＇s myoclonic seizures disappeared.On day 6 of treatment,the EEG revealed sporadic spike-and-slow-wave complexes and slow waves.Twelve days after admission,the patient＇s condition was stable, and she was discharged.

关 键 词：进行性肌阵挛癫痫 苯妥英钠 非惊厥性癫痫持续状态 

分 类 号：R742.1[医药卫生—神经病学与精神病学]