E2A、EBF和PAX5在早期B细胞分化发育中的作用  

Roles of E2A,EBF and PAX5 in early B cell development and differentiation

作　　者：王旭[1] 逄越[1] 王惠国[1] 刘庆平[1] 李文哲[1] 

机构地区：[1]大连大学生物工程学院免疫研究所,116622

出　　处：《免疫学杂志》2011年第10期910-912,917,共4页Immunological Journal

基　　金：国家自然科学基金(30972675)

摘　　要：早期B细胞分化发育受到各种转录因子调控,特别是转录因子E2A、早期B细胞因子(EBF)及PAX5的调控尤为重要。本文以E2A、EBF与PAX5三个转录因子为综述对象,逐一阐述其在早期B细胞分化发育中的作用,并对3个转录因子在早期B细胞分化发育中的协同作用进行了综述。本文将为"B淋巴细胞分化发育调控机理研究"提供参考。Differentiation and development of early B lymphocytes are regulated by many transcription factors,especially E2A,early B cell factor（EBF） and PAX5.In this review,we severally explained the role of transcription factors E2A,EBF and PAX5 and summarized the hierarchical regulatory network of them in early B cell differentiation and development.This review would provide references as ＂the research of B lymphocytes differentiation and development regulation mechanism ＂.

关 键 词：E2A EBF PAX5 早期B细胞 分化发育 

分 类 号：R392.11[医药卫生—免疫学]