五元氮杂环阿魏酸衍生物的合成  

Synthesis of Five-Membered Nitrogen-Containing Heterocycle Ferulic Acid Derivatives

作　　者：许勤龙[1] 李家明[1] 王融融[1] 周鹏[1] 邬皓[1] 袁明[1] 

机构地区：[1]安徽中医学院药学院安徽省现代中药重点实验室,安徽合肥230031

出　　处：《安徽化工》2011年第5期19-23,共5页Anhui Chemical Industry

基　　金：国家科技重大专项重大新药创制项目(批准号:2009ZX09103-123);安徽省高校自然基金重点项目(批准号:KJ2010A206)

摘　　要：目的:合成4个五元氮杂环阿魏酸衍生物。方法:以阿魏酸乙酯为起始原料,经Williamson醚化、亲核取代反应和水解反应,合成五元氮杂环阿魏酸衍生物。结果:所合成的目标化合物未见文献报道,目标化合物的结构经IR、1H-NMR、13C-NMR及MS确证。结论:所设计的合成技术简单易行。Objective：To synthesize four five-membered Nitrogen-containing heterocycle ferulic acid derivatives.Methods：Ferulic acid ethyl ester,imidazole and triazole were used as starting material.The target compounds were synthesized from aryl esters via Willamson etherification,nucleophilic substitution,and hydroxylation.Results： The target compounds have not been reported.The chemical structures were confirmed by IR,1H-NMR,13C-NMR and MS.Conclusion： This synthetic technique is simple and feasible.

关 键 词：阿魏酸 抗血小板聚集 合成 

分 类 号：R284.3[医药卫生—中药学]