Annexin A4在结直肠癌中的表达及意义  

Expression and significance of Annexin A4 in colorectal cancer

作　　者：蔡观福[1] 王俊江[1] 吴德庆[1] 李勇 吴伍林[1] 余清华[1] 姚学清[1] 林锋[1] 

机构地区：[1]广东省人民医院广东省医学科学院胃肠肿瘤外科,广州510080

出　　处：《广东医学》2011年第20期2655-2657,共3页Guangdong Medical Journal

基　　金：广东省自然科学基金资助项目(编号:5301056;S2011010001430);广东省科技计划项目(编号:2007B080701017)

摘　　要：目的研究Annexin A4在结直肠癌组织中的表达及意义,以探讨结直肠癌的发生机制。方法采用Western blot的方法对正常结直肠组织以及Dukes A、B、C、D期结直肠癌组织进行Annexin A4及其磷酸化检测。结果在正常组织及结直肠癌组织中Annexin A4和其磷酸化均有表达,Annexin A4在Dukes A和B期表达最高,Dukes C和D期略低于正常组织,磷酸化Annexin A4在Dukes A期表达最高,Dukes B、C和D期与正常组织差异无统计学意义。结论结直肠癌组织中Annexin A4的异常表达与结直肠癌的发生发展是相关的。Objective To investigate the expression and significance of Annexin A4 in colorectal cancer. Methods Annexin A4 with and without phosphorylation in the normal colorectal tissues and colorectal cancer tissues in Dukes A, B, C, D period were assessed with Western blot. Results Annexin A4, with and without phosphorylation, were both detected in normal and eolorectal cancer tissues. The expression of Annexin A4 was highest in Dukes A and B colorectal cancer tissues, while lower expression was revealed in Dukes C and D colorectal cancer tissues than that in normal controis. The highest phosphorylated Annexin A4 expression was noted in the Dukes A colorectal cancer tissue, while there was no difference among normal tissue and Dukes B, C and D cancer tissues. Conclusion The abnormal expression and phosphorylation of Annexin A4 contributes to the oncogenesis of coloreetal cancer.

关 键 词：ANNEXIN A4 结直肠癌 

分 类 号：R735.3[医药卫生—肿瘤]