碘代醚类化合物的合成研究  

Synthesis of iodo-substituted ethers

作　　者：钟燕[1] 梁占超[1] 刘靖[1] 张首国[1] 温晓雪[1] 彭涛[1] 王林[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京100850

出　　处：《化学试剂》2011年第10期871-872,918,共3页Chemical Reagents

基　　金：国家自然科学基金资助项目(307706558;1072531;30472081)

摘　　要：碘代化合物是有机合成化学中的一种重要的中间体。探索了碘代醚类化合物的合成方法。以己二醇为原料,经碘代、成醚,碘化合成了碘代硫醚类化合物,产率达23.5%。以己二醇单碘代中间体为原料,经保护、成醚、脱保护,碘化合成了碘代醚类化合物,产率达30.5%。本合成方法工艺简便、条件温和、原料易得。The iodo-substitued compounds are the important intermediates in organic synthesis.The synthesis of iodo-substituted ethers were investigated.Hexanediol,as the starting material,was subjected to iodo-substitution,etherification and iodination to give iodo-substituted sulfides.The total yield was 30.5%.The mono-iodo-substitueted intermediate was subjected to protection,etherification,deprotection and iodination to give iodo-substituted ethers.The total yield was 30.5%.The starting material is very easy to be obtained,the reaction conditions are moderate and the operation is convenient.

关 键 词：碘代脂肪烷 碘代 中间体 合成 

分 类 号：TQ124.6[化学工程—无机化工]