脐带间充质干细胞移植治疗帕金森病8例  

Umbilical cord mesenchymal stem cell transplantation for treatment of Parkinson's disease in 8 cases

作　　者：邱云[1,2] 汪铮[1,2] 路红社[3] 

机构地区：[1]上海交通大学医学院附属仁济医院消化科消化疾病研究所 [2]上海交通大学Med-X实验室,上海市200001 [3]解放军455医院干细胞移植中心,上海市200135

出　　处：《中国组织工程研究与临床康复》2011年第36期6833-6836,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：上海市科委浦江人才计划项目(09PJ1407300);国家自然科学基金资助项目(30971468)~~

摘　　要：背景：中枢神经系统的神经细胞是一种终末细胞,任何病理过程导致的神经元丢失都将是一个不可逆过程。目的：观察间充质干细胞移植治疗帕金森病患者神经功能的效果。方法：选择2010-08/11上海455医院干细胞移植中心收治的帕金森病患者8例,男4例,女4例,年龄50~78岁。所有患者均住院治疗,自第2周起应用脐带间充质干细胞进行颈动脉穿刺移植治疗,采用帕金森病统一评分量表（Unified Parkinson＇s Disease Rating Scale,UPDRS）对患者移植前后神经功能进行评定,分值越高表示神经功能缺损越严重。结果与结论：8例患者均进入结果分析。与移植前相比,8例患者移植后1个月帕金森病统一评分量表分值均明显降低（P〈0.05）,主要集中在对震颤、强直的改善,而运动迟缓、姿势不稳等临床症状无明显改善。8例患者均未出现移植物抗宿主病。提示脐带间充质干细胞移植可以一定程度地改善帕金森病患者的临床症状,提高患者生活质量。BACKGROUND：Neurons of the central nervous system neurons are a kind of terminal cells,and neuron loss caused by any pathological process is an irreversible process.OBJECTIVE：To observe the curative effect of umbilical cord mesenchymal stem cells（UC-MSCs） implantation in treating Parkinson＇s disease（PD）.METHODS：A total of 8 PD patients admitted in the Stem Cells Transplantation Center,the 455 Hospital of Chinese PLA,from August to December 2010,were selected,including 4 males and 4 females,aged 50-78 years.From the second week,the patients received UC-MSCs implantation by carotid artery puncturing.Unified Parkinson＇s Disease Rating Scale（UPDRS） was used to evaluate those PD patients＇ neural function.Higher scores indicate more severe neurological deficit.RESULTS AND CONCLUSION：All patients were included in the final analysis without loss.Compared to before transplantation,the UPDRS was significant decreased at 1 month after treatment（P 0.01）.The clinical symptoms,such as tremor,rigidity had obvious improvement.There was no significant improvement concerning the symptoms of slow movement and unstable posture.In addition,no graft versus host disease occurred.UC-MSCs implantation can ameliorate clinical symptoms,as well as improve life quality of PD patients to some extent.

关 键 词：脐带间充质干细胞 细胞移植 帕金森病 神经变性 震颤 强直 

分 类 号：R394.2[医药卫生—医学遗传学]