杜仲雄花脂溶性生物碱的镇静催眠作用研究  

Study on Sedative and Hypnotic Effects of Fat-soluble Alkaloids in Eucommia Male Flowers

作　　者：李欣[1] 刘严[1] 樊金玲[1] 罗磊[1] 郭菡[1] 

机构地区：[1]河南科技大学食品与生物工程学院,河南洛阳471003

出　　处：《包装与食品机械》2011年第5期9-12,40,共5页Packaging and Food Machinery

基　　金：河南省教育厅自然科学基金项目(2006550001);河南科技大学科研创新能力培育基金(2009CZ0015)

摘　　要：目的:研究不同剂量杜仲雄花脂溶性生物碱的镇静催眠作用。方法:采用酸水提取法提取杜仲雄花中脂溶性生物碱。观察不同剂量杜仲雄花脂溶性生物碱对小鼠自主活动的影响以及直接镇静催眠作用,与戊巴比妥钠的协同作用和抗惊厥作用。结果:杜仲雄花脂溶性生物碱能有效减少小鼠的自主活动数;与戊巴比妥钠有良好的协同作用,阈下剂量的戊巴比妥钠能增加小鼠睡眠率并延长睡眠时间;阈上剂量的戊巴比妥钠能显著延长睡眠时间并缩短睡眠潜伏期;杜仲雄花脂溶性生物碱还能有效地降低尼可刹米所致的小鼠惊厥率。结论:杜仲雄花脂溶性生物碱具有良好的镇静催眠作用。Objective： Study the sedative and hypnotic effects of fat-soluble alkaloids of Eucommia male flowers with different dose.Methods： The fat-soluble alkaloids were extracted from the Eucommia male flowers in acid.We investigated the effects on spontaneous activity of mice,the synergistic effect with pentobarbital sodium,and anticonvulsant effects of fat-soluble alkaloids in Eucommia male flowers with different dose.Results： Fat-soluble alkaloids of Eucommia male flowers could significantly inhibit the spontaneous activity;enhance the action on mice sleeping ratio and prolong the sleeping time of pentobarbital sodium with subthreshold dose;prolong the sleeping time and shorten the sleeping latency of pentobarbital sodium with superthreshold dose;effectly reduce the eclamptic ratio of mice.Conclusion： Fat-soluble alkaloids of Eucommia male flowers possess obviously sedative and hypnotic effects in mice.

关 键 词：杜仲雄花 脂溶性生物碱 镇静 催眠 

分 类 号：TS218.2[轻工技术与工程—粮食、油脂及植物蛋白工程] R285.5[轻工技术与工程—食品科学与工程]