A family study of endophenotypes for psychosis within an early intervention programme in Hong Kong: Rationale and preliminary findings  

作　　者：LUI Simon S Y SHAM Pak CHAN Raymond C K CHEUNG Eric F C 

机构地区：[1]Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences [2]Graduate University of Chinese Academy of Sciences [3]Castle Peak Hospital [4]Department of Psychiatry, the University of Hong Kong

出　　处：《Chinese Science Bulletin》2011年第32期3394-3397,共4页

基　　金：supported by the Project-Oriented Hundred Talents Programme (O7CX031003);the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-YW-R-131, KSCX2-EW-J-8);a grant from the National Science Fund for Distinguished Young Scholars(81088001) to Raymond Chan

摘　　要：The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis, but this research direction is relatively under-developed in China as compared to Western countries. We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains (neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure) are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011.The study of endophenotypes may be a viable strategy to tackle the genetic complexity and phenotypic heterogeneity of psychosis but this research direction is relatively under-developed in China as compared to Western countries, We have recently initiated one of the first family studies of endophenotypes for psychosis in China. Patients entering an established early psychosis intervention service are recruited into this research project for phenotyping, endophenotyping and genotyping. At the endophenotypic level, four domains （neurological soft signs, neurocognition of prospective memory, social cognition of facial emotion recognition, and affective cognition of anticipatory and consummatory pleasure） are studied in the sample of patients with psychosis and their unaffected siblings. This article illustrates the benefit of a research-oriented clinical programme and its findings based on the data collected as of early 2011.

关 键 词：精神病患者 稳定 家庭 早期 原理 预计 香港 面部表情识别 

分 类 号：R749[医药卫生—神经病学与精神病学]