Relationship between platelet P-selectin and severity of acute coronary syndromes  

作　　者：Rui Wang~1 Jiyuan Lu~1 Yongping Jia~1 Yuping Gao~1 Chunyu Fan~1 Fang Li~2 1 Department of Cardiology, The First Hospital of Shanxi Medical University. 2 Department of Biochemisry and Molecular Biology, Shanxi Medical University. Taiyuan, Shanxi 030001, China 

出　　处：《Journal of Geriatric Cardiology》2008年第3期146-149,共4页老年心脏病学杂志（英文版）

摘　　要：Objective Recent studies reveal important roles ofplatelet P-selectin on progression of atherosclerosis.In the present study, we examine the relation between platelet P-selectin expression and severity of acute coronary syndromes.Methods One hundred and eighty-four consecutive patients with proven or clinically suspected acute coronary syndromes (ACS) were enrolled in the study. Level of P-selectin expression was determined by flow cytometry.Platelet P-selectin level was expressed as the percentage of P- selectin positive platelet.Results The level of P-selectin was higher in patients with a single diseased coronary artery or multiple diseased arteries compared to those with normal coronary arteries.P-selectin expression was significantly and positively correlated with angiographic Gensini score (r=0.323,P=0.029).Multiple regression analyses showed that the association of the percentage of P- selectin-positive platelets with ACS was independent of other clinical factors.Conclusions Platelet P-selectin is associated with severity of acute coronary syndromes in patients with acute coronary syndromes.Objective Recent studies reveal important roles of platelet P-seleetin on progression of atherosclerosis.In the present study,we examine the relation between Platelet P-selectin expression and severity of acute coronary syndromes.Methods One hundredand eighty-four consecutive patients with proven or clinically suspected acute coronary syndromes(ACS)were enrolled in the study.Level of P-selectin expression was determined bv flow cytometry.Platelet P-selectin level was expressed as the percentage of P-selectin positive platelet.Results The level of P-selectin was higher in patients with a single diseased coronary artery or multiplediseased arteries compared to thOSe with normal coronary arteries.P-selectin expression was significantly and positively correlatedwith angiographic Gensini score(r=0.323,P=0.029).Multiple regression analyses showed that the association of the percentage of P-selectin-positive platelets with ACS was independent of other clinical factors. Conclusions Platelet P-selectin is associated withseverity of acute coronary syndromes in patients with acute coronary syndromes.

关 键 词：PLATELETS P-SELECTIN acute CORONARY SYNDROMES 

分 类 号：R541.4[医药卫生—心血管疾病]