Cilia and ciliopathies:From Chlamydomonas and beyond  

作　　者：PAN JunMin Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China 

出　　处：《Science China(Life Sciences)》2008年第6期479-486,共8页中国科学（生命科学英文版）

基　　金：the National Natural Science Foundation of China (Grant Nos. 30671090 and 30771084);National Basic Research Program of China ("973" Program) (Grant No. 2007CB914401)

摘　　要：The biological function of motile cilia/flagella has long been recognized. The non-motile primary cilium, once regarded as a vestigial organelle, however, has been found recently to play unexpected roles in mammalian physiology and development. Defects in cilia have profound impact on human health. Diseases related to cilia, collectively called ciliopathies include male infertility, primary cilia dyskinesia, renal cyst formation, blindness, polydactyly, obesity, hypertension, and even mental retardation. Our current understanding of cilia and ciliopathies has been fueled by basic research employing various model organisms including Chlamydomonas, a unicellular green alga. This review article provides a general introduction to the cell biology of cilia and an overview of various cilia-related diseases.The biological function of motile cilia/flagella has long been recognized. The non-motile primary cilium, once regarded as a vestigial organelle, however, has been found recently to play unexpected roles in mammalian physiology and development. Defects in cilia have profound impact on human health. Diseases related to cilia, collectively called ciliopathies include male infertility, primary cilia dyskinesia, renal cyst formation, blindness, polydactyly, obesity, hypertension, and even mental retardation. Our current understanding of cilia and ciliopathies has been fueled by basic research employing various model organisms including Chlamydomonas, a unicellular green alga. This review article provides a general introduction to the cell biology of cilia and an overview of various cilia-related diseases.

关 键 词：CHLAMYDOMONAS CILIA flagellla human DISEASE CILIOPATHY 

分 类 号：Q944[生物学—植物学]