党参多糖抗衰老作用机制的实验研究  

Study effect and its mechanism on resisting senility of PCPN

作　　者：许爱霞[1] 张振明[1] 葛斌[1] 蒲君峰[1] 

机构地区：[1]甘肃省人民医院药剂科,兰州730000

出　　处：《中国现代应用药学》2006年第S2期729-731,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的研究党参多糖的抗衰老作用及其机制。方法用D-半乳糖致衰老模型小鼠,同时党参多糖50或150mg.kg-1.d-1连续灌胃8周,观察其对衰老模型小鼠器官及系统功能的影响。结果50或150mg.kg-1.d-1党参多糖能使衰老模型小鼠胸腺指数和脾脏指数升高,血清和肝组织中MDA明显下降及SOD活力明显上升,脑组织中LF明显下降,肾组织中GSH-PX活力及NOS活力明显升高。结论党参多糖有抗衰老作用,其机制可能与增强机体免疫功能,清除自由基及抗脂质过氧化有关。OBJECTIVE To study effect and its mechanism of polysaccharide from Codonopsis Pilosula Nannf.(PCPN) on resisting senility.METHODS To observe effect on organs and systems of rats with senile model caused by D-galatose(D-gal) and meanwhile administered 50 or 150mg·kg^(-1)·d^(-1) PCPN. RESULTS Thymus index and spleen index notably rose,MDA notably dropped and SOD notably ascended in serums and livers,LF notably descended in brains,activities of GSH-PX and NOS notably rose in kidneys of rats with senile model administered PCPN.CONCLUSION PCPN may postpone senility,its mechanism probably connected with rising immunity,eliminating free radicals,antilipoperoxidation.

关 键 词：党参多糖 抗衰老作用 清除自由基 抗脂质过氧化 提高免疫功能 

分 类 号：R285.5[医药卫生—中药学]