Genetic polymorphism of CYP2D6 in Karnataka and Andhra Pradesh population in India  

CYP2D6在印度卡纳塔克邦和安得拉邦人群中的遗传多态性(英文)

作　　者：Benny K ABRAHAM C ADITHAN P USHA KIRAN Mohammed ASAD K KOUMARAVELOU 

机构地区：[1]Clinical Pharmacology Unit,Department of Pharmacology,Jawaharlal Institute of Post-graduate Medical Education and Research,Pondicherry-605 006,India [2]Department of Pharmacology,Rangaraya Medical College,Kakinada-533 008,Andhra Pradesh,India

出　　处：《Acta Pharmacologica Sinica》2000年第6期16-20,共5页中国药理学报（英文版）

摘　　要：AIM: To study the prevalence of cytochrome P-450 2D6 (CYP2D6) polymorphism in Kamataka ( KA) and Andhra Pradesh (AP) population. METHODS: Two hundred and eleven healthy human volunteers participated in the study (100 from KA and 111 from AP). At bed time, after voiding their bladder, the volunteers ingested 30 mg of dextromethorphan hydrobromide (DM). Urine samples were collected for 8 h. DM and its metabolite dextrorphan ( DT) were estimated in the urine using HPLC. The metabolic ratio (DM/DT) was used for phenotyping. RESULTS: The prevalence of poor metabolisers (PM) in KA is 4 % and AP is 1.8 %. CONCLUSION: The frequency of PM phenotype in South Indian population is in between the Western and Oriental population.AIM: To study the prevalence of cytochrome P-450 2D6 (CYP2D6) polymorphism in Kamataka ( KA) and Andhra Pradesh (AP) population. METHODS: Two hundred and eleven healthy human volunteers participated in the study (100 from KA and 111 from AP). At bed time, after voiding their bladder, the volunteers ingested 30 mg of dextromethorphan hydrobromide (DM). Urine samples were collected for 8 h. DM and its metabolite dextrorphan ( DT) were estimated in the urine using HPLC. The metabolic ratio (DM/DT) was used for phenotyping. RESULTS: The prevalence of poor metabolisers (PM) in KA is 4 % and AP is 1.8 %. CONCLUSION: The frequency of PM phenotype in South Indian population is in between the Western and Oriental population.

关 键 词：cytochrome P-450 CYP2D6 human INDIA high pressure liquid chromatography DEXTROMETHORPHAN PHENOTYPE polymorphism (genetics) 

分 类 号：Q987[生物学—遗传学]