云南高校图书馆联盟文献共享服务平台- DEXTROMETHORPHAN

DEXTROMETHORPHAN: 作品数：9被引量：19H指数：3; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：陈冰刘玉秀蔡卫民孙凤艳印克杰更多>>; 相关机构：南京军区南京总医院上海医科大学更多>>; 相关期刊：《Acta Pharmacologica Sinica》《Neural Regeneration Research》《World Journal of Clinical Cases》《Neuroscience Bulletin》更多>>

Anti-epileptic and Neuroprotective Effects of Ultra-low Dose NADPH Oxidase Inhibitor Dextromethorphan on Kainic Acid-induced Chronic Temporal Lobe Epilepsy in Rats被引量：2: 《Neuroscience Bulletin》2024年第5期577-593,共17页Jing-Jing Yang Ying-Xin Liu Yan-Fang Wang Bi-Ying Ge Ying Wang Qing-Shan Wang Sheng Li Jian-Jie Zhang Ling-Ling Jin Jau-Shyong Hong Sheng-Ming Yin Jie Zhao; supported by the National Major Scientific and Technological Special Project for Significant New Drugs Development(2019zx09301102);the Project of Liaoning Provincial Department of Education(LJKZ0826);the Open Project of National and Local Joint Engineering Research Center for Drug Research and Development of Neurodegenerative Diseases(2022GCYJZX-YB02).; Neuroinflammation mediated by microglia and oxidative stress play pivotal roles in the development of chronic temporal lobe epilepsy(TLE).We postulated that kainic acid(KA)-Induced status epilepticus triggers microgli...; 关键词：Temporal lobe epilepsy DEXTROMETHORPHAN NADPH oxidase Ultra-low dose

High doses of dextromethorphan induced shock and convulsions in a 19-year-old female:A case report: 《World Journal of Clinical Cases》2023年第16期3870-3876,共7页Shintaro Shimozawa Daisuke Usuda Toru Sasaki Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Yuta Hotchi Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Suguru Asako Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita; BACKGROUND Dextromethorphan is a prevalent antitussive agent that can be easily obtained as an over-the-counter medication.There has been a growing number of reported cases of toxicity in recent years.Generally,there ...; 关键词：DEXTROMETHORPHAN Drug overdose Shock SYMPTOM Treatment Case report

Deuterated dextromethorphan/quinidine for agitation in Alzheimer's disease: 《Neural Regeneration Research》2022年第5期1013-1014,共2页Rita Khoury; Alzheimer's disease(AD)is the most common type of neurode generative disorder;it affects around 47 million individuals worldwide(Prince et al.,2013).AD rose from the 12 th most burdensome disease in the United States ...; 关键词：ALZHEIMER AGITATION

Evidence for using dextromethorphan-quinidine for the treatment of agitation in dementia: 《World Journal of Psychiatry》2020年第4期29-33,共5页Rajesh R Tampi Pallavi Joshi Padmapriya Marpuri Deena J Tampi; Behavioral and psychological symptoms including agitation are common in dementia,and are associated with decreased quality of life,increased risk of institutionalization,and greater patient and caregiver distress.Phar...; 关键词：DEXTROMETHORPHAN QUINIDINE AGITATION DEMENTIA Behavioral and psychological SYMPTOMS of DEMENTIA

A new look at auranofin,dextromethorphan and rosiglitazone for reduction of glia-mediated inflammation in neurodegenerative diseases被引量：4: 《Neural Regeneration Research》2015年第3期391-393,共3页Jocelyn M.Madeira Stephanie M.Schindler Andis Klegeris; supported by a grant from the Jack Brown;Family Alzheimer’s Disease Research Foundation; Neurodegenerative disorders including Alzheimer＇s disease are characterized by chronic in- flammation in the central nervous system. The two main glial types involved in inflammatory reactions are microglia and astro...; 关键词：AURANOFIN DEXTROMETHORPHAN ROSIGLITAZONE Alzheimer＇s disease neuroinflammation NEURODEGENERATION rnicroglia ASTROCYTES

Modulation of the pentose phosphate pathway alters phase I metabolism of testosterone and dextromethorphan in HepG2 cells被引量：3: 《Acta Pharmacologica Sinica》2015年第2期259-267,共9页Wen-jing XIAO Ting MA Chun GE Wen-juan XIA Yong MAO Run-bin SUN Xiao-yi YU Ji-ye AA Guang-ji WANG; Aim： The pentose phosphate pathway （PPP） is involved in the activity of glucose-6-phosphate dehydrogenase （G6PD） and generation of NADPH, which plays a key role in drug metabolism. The aim of this study was to in...; 关键词：drug metabolism HepG2 cells pentose phosphate pathway G6PD p53 CYP TESTOSTERONE DEXTROMETHORPHAN KETOCONAZOLE QUINIDINE cyclic PFT-a NSC 66811 6-aminonicotinamide MENADIONE

Genetic polymorphism of CYP2D6 in Karnataka and Andhra Pradesh population in India: 《Acta Pharmacologica Sinica》2000年第6期16-20,共5页Benny K ABRAHAM C ADITHAN P USHA KIRAN Mohammed ASAD K KOUMARAVELOU; AIM: To study the prevalence of cytochrome P-450 2D6 (CYP2D6) polymorphism in Kamataka ( KA) and Andhra Pradesh (AP) population. METHODS: Two hundred and eleven healthy human volunteers participated in the study (100 ...; 关键词：cytochrome P-450 CYP2D6 human INDIA high pressure liquid chromatography DEXTROMETHORPHAN PHENOTYPE polymorphism (genetics)

Neuroprotective action of dextromethorphan in rat photochemically-induced focal cerebral ischemia: 《中国药理学报》1998年第3期223-226,共4页印克杰孙凤艳; 目的：研究右美沙芬在脑缺血中的作用和机制．方法：采用光化学脑缺血模型，在缺血前１５分钟，腹腔注射１２５，２５，５０ｍｇ·ｋｇ－１的右美沙芬，观察对损伤区体积、局部脑血流量和ｂｃｌ２／ｂａｘ表达的影响．结果：右美沙...; 关键词：右美沙芬脑缺血神经保护剂光化学

Dextromethorphan　metabolic　phenotyping　in　a　Chinese　population被引量：10: 《中国药理学报》1997年第5期441-444,共4页蔡卫民陈冰刘玉秀初晓; 目的：建立中国人右美沙芬（ＤＭ）氧化代谢多态性的表型分型．方法：１２０名无血缘关系的中国人口服ＤＭ２０ｍｇ后，测定其尿中ＤＭ及其代谢物右啡烷（ＤＸ）浓度，并计算代谢比值（ＭＲ）．结果：氧化代谢缺陷率为０８％（１人）...; 关键词：右美沙芬多态性显型遗传药理学

DEXTROMETHORPHAN